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Published TCIMAIL newest issue No.198
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CAS RN: 26807-65-8 | Product Number: I0730
Indapamide
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Purity: >97.0%(T)(HPLC)
Synonyms:
- 1-(4-Chloro-3-sulfamoylbenzamido)-2-methylindoline
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
€35.00
|
Contact Us | 5 |
|
| 5G |
€121.00
|
1 | 26 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | I0730 |
| Purity / Analysis Method | >97.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__6H__1__6ClN__3O__3S = 365.83 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 26807-65-8 |
| Reaxys Registry Number | 1604026 |
| PubChem Substance ID | 87561081 |
| Merck Index (14) | 4935 |
| MDL Number | MFCD00079375 |
Specifications
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(Neutralization titration) | min. 97.0 % |
| Melting point | 167.0 to 173.0 °C |
Properties (reference)
| Melting Point | 170 °C |
GHS
Related Laws:
| EC Number | 248-012-7 |
| RTECS# | CV2451200 |
Transport Information:
| HS Number | 2935909099 |
Application
Indapamide: A Thiazide-Like Antihypertensive/Diuretic Agent
Indapamide is a thiazide-like antihypertensive/diuretic agent. Incidentally, thiazide diuretic agents include hydrochlorothiazide [H1274] and xipamide. Indapamide molecule contains both a polar sulfamoyl chlorobenzamide moiety and a lipid-soluble methylindoline moiety. Indapamide have a mild diuretic activity and a peripheral vasodilatory effect. The mechanism of action has not been completely elucidated, but indapamide affects the distal convoluted tubules, where they inhibit Na+/Cl- cotransport in the luminal membrane of tubule cells. Thus, reabsorption of NaCl and water is inhibited. (The product is for research purpose only.)
References
- Pharmacokinetics and metabolism of indapamide: a review
- The pharmacology and clinical pharmacology of indapamide
- Pharmacological properties of indapamide: rationale for use in hypertension (a review)
- Indapamide sustained release: a review of its use in treatment of hypertension (a review)
- Comparison of spectrophotometric and an LC method for the determination perindopril and indapamide in pharmaceutical formulations
PubMed Literature
Product Articles
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