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Published TCIMAIL newest issue No.198
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CAS RN: 482-44-0 | Product Number: I0904
Imperatorin
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Purity: >98.0%(HPLC)
Synonyms:
- 8-(3-Methyl-2-butenyloxy)psoralen
- 8-Prenyloxypsoralen
- Marmelosin
- 9-[(3-Methyl-2-buten-1-yl)oxy]-7H-furo[3,2-g]chromen-7-one
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25MG |
€120.00
|
1 | 17 |
|
| 100MG |
€325.00
|
1 | 12 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | I0904 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__6H__1__4O__4 = 270.28 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 25MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 482-44-0 |
| Reaxys Registry Number | 249728 |
| PubChem Substance ID | 354334057 |
| Merck Index (14) | 4925 |
| MDL Number | MFCD00016881 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 97.0 to 101.0 °C |
Properties (reference)
| Melting Point | 99 °C |
| Maximum Absorption Wavelength | 301 nm (MeOH) |
| Solubility in water | Insoluble |
| Solubility (soluble in) | Ether, Acetone, Alcohol, Benzene |
GHS
Related Laws:
| EC Number | 207-581-1 |
| RTECS# | LV1575000 |
Transport Information:
| HS Number | 2932209090 |
Application
Imperatorin: An Inhibitor of Cyclin D1 Expression
Imperatorin is a furanocoumarin and a phytochemical isolated from herbal medicines such as Angelica dahurica. Imperatorin strongly inhibits cyclin D1 expression and arrests the cells at the G1 phase of the cell cycle. It is reported that imperatorin shows potent pharmacological activities including anticonvulsant, vasodilatation, antitumor, anti-inflammatory activities and affecting the activities of drug-metabolizing enzymes. (The product is for research purpose only.)
References
- Imperatorin Inhibits HIV-1 Replication through an Sp1-dependent Pathway
- Anticonvulsant and acute neurotoxic effects of imperatorin, osthole and valproate in the maximal electroshock seizure and chimney tests in mice: A comparative study
- Imperatorin induces vasodilatation possibly via inhibiting voltage dependent calcium channel and receptor-mediated Ca2+ influx and release
- Anticancer effects of imperatorin isolated from Angelica dahurica: induction of apoptosis in HepG2 cells through both death-receptor- and mitochondria-mediated pathways
- Inducible Nitric Oxide Synthase and Cyclooxygenase-2 Participate in Anti-inflammatory Activity of Imperatorin from Glehnia littoralis
- Simultaneous determination of scopoletin, psoralen, bergapten, xanthotoxin, columbianetin acetate, imperatorin, osthole and isoimperatorin in rat plasma by LC-MS/MS for pharmacokinetic studies following oral administration of Radix Angelicae Pubescentis extract
- Solubility of imperatorin in ethanol + water mixtures
PubMed Literature
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