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Published TCIMAIL newest issue No.199
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CAS RN: 22204-53-1 | Product Number: M1021
(S)-(+)-2-(6-Methoxy-2-naphthyl)propionic Acid
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Purity: >99.0%(GC)(T)
Synonyms:
- (S)-(+)-6-Methoxy-α-methyl-2-naphthaleneacetic Acid
- Naproxen
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25G |
€60.00
|
12 | ≥40 |
|
| 500G |
€543.00
|
1 | 6 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | M1021 |
Purity / Analysis Method 
|
>99.0%(GC)(T) |
| Molecular Formula / Molecular Weight | C__1__4H__1__4O__3 = 230.26 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Condition to Avoid | Light Sensitive |
| CAS RN | 22204-53-1 |
| Reaxys Registry Number | 3591067 |
| PubChem Substance ID | 87572993 |
| SDBS (AIST Spectral DB) | 19020 |
| Merck Index (14) | 6417 |
| MDL Number | MFCD00010500 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 99.0 % |
| Purity(Neutralization titration) | min. 99.0 % |
| Melting point | 155.0 to 158.0 °C |
| Specific rotation [a]20/D | +65.0 to +70.0 deg(C=1, CHCl3) |
Properties (reference)
| Melting Point | 155 °C |
| Specific Rotation | 67.5° (C=1,CHCl3) |
| Solubility in water | Insoluble |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. H361 : Suspected of damaging fertility or the unborn child. |
| Precautionary Statements | P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. |
Related Laws:
| EC Number | 244-838-7 |
| RTECS# | UF5275000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| HS Number | 2918999090 |
Application
(S)-Naproxen: A Nonselective COX-1 and COX-2 Enzymes Inhibitor
(S)-Naproxen, a propionic acid derivative with a naphthalene nucleus, is a nonselective nonsteroidal anti-inflammatory drug (NSAID) and the pharmacologically active enantiomer of (±)-naproxen [M1220]. (S)-Naproxen works by reversibly inhibiting both the COX-1 and COX-2 enzymes. It had twice the potency of (S)-(+)-ibuprofen [I0549] and a longer half-life (ca. 12 hours). (S)-naproxen is a more active form than the (R)-naproxen which causes liver damage. (The product is for research purpose only.)
References
- Naproxen. A reappraisal of its pharmacology, and therapeutic use in rheumatic diseases and pain states (a review)
- Clinical pharmacokinetics of naproxen (a review)
- Twenty years of naproxen technology (a review)
- Photoreactivity of the nonsteroidal anti-inflammatory 2-arylpropionic acids with photosensitizing side effects (a review)
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