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Published TCIMAIL newest issue No.198
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CAS RN: 56392-17-7 | Product Number: M2555
Metoprolol Tartrate
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 1-(Isopropylamino)-3-[4-(β-methoxyethyl)phenoxy]-2-propanol (+)-Tartrate
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
57,00 €
|
8 | 39 |
|
| 25G |
196,00 €
|
1 | 14 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | M2555 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__5H__2__5NO__3·^^1/__2C__4H__6O__6 = 342.41 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 56392-17-7 |
| Related CAS RN
|
51384-51-1 |
| PubChem Substance ID | 253662413 |
| Merck Index (14) | 6151 |
| MDL Number | MFCD00056257 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 120.0 to 124.0 °C |
| Specific rotation [a]20/D | +7.0 to +10.0 deg(C=2, H2O) |
Properties (reference)
| Melting Point | 123 °C |
| Specific Rotation | 9° (C=2,H2O) |
| Maximum Absorption Wavelength | 223 nm (H__2O) |
| Solubility in water | Soluble |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H361 : Suspected of damaging fertility or the unborn child. H362 : May cause harm to breast-fed children. |
| Precautionary Statements | P263 : Avoid contact during pregnancy and while nursing. P260 : Do not breathe dust. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. |
Related Laws:
| EC Number | 260-148-9 |
| RTECS# | UB7450100 |
Transport Information:
| HS Number | 2922500090 |
Application
Metoprolol Tartrate: A Selective β1-Adrenoceptor Antagonist (β1-Blocker)
Metoprolol tartrate is a selective β1-adrenoceptor antagonist (β1-blocker) which lacks intrinsic sympathomimetic activity (ISA). Metoprolol tartrate is widely used for the treatment of mild to moderate hypertension and angina pectoris. Metoprolol is metabolised by cytochrome P-450 (CYP) isoenzymes CYP2D6 in liver. Controlled release formulations of metoprolol tartrate, and combined of metoprolol tartrate and felodipine [F0814] (a selective dihydropyridine Ca2+ channel antagonist) have been reported. (The product is for research purpose only.)
References
- Metoprolol. An updated review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy, in hypertension, ischemic heart disease and related cardiovascular disorders (a review)
- Metoprolol: A review of its use in chronic heart failure (a review)
- Metoprolol metabolism via cytochrome P4502D6 in ethnic populations
- A sensitive assay of metoprolol and its major metabolite α-hydroxy metoprolol in human plasma and determination of dextromethorphan and its metabolite dextrorphan in urine with high performance liquid chromatography and fluorometric detection
- Development of metoprolol tartrate extended-release matrix tablet formulations for regulatory policy consideration
- Felodipine/metoprolol: a review of the fixed dose controlled release formulation in the management of essential hypertension (a review)
PubMed Literature
Product Documents (Note: Some products will not have analytical charts available.)
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