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CAS RN: 55481-88-4 | Product Number: M3091
Mollugin
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Purity: >98.0%(HPLC)
Synonyms:
- Methyl 6-Hydroxy-2,2-dimethyl-2H-benzo[h]chromene-5-carboxylate
- 6-Hydroxy-2,2-dimethyl-2H-benzo[h]chromene-5-carboxylic Acid Methyl Ester
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 10MG |
65,00 €
|
1 | 7 |
|
|
| 50MG |
208,00 €
|
Contact Us | 4 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | M3091 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__7H__1__6O__4 = 284.31 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 55481-88-4 |
| Reaxys Registry Number | 1433506 |
| PubChem Substance ID | 468592264 |
| MDL Number | MFCD02752331 |
Specifications
| Appearance | White to Yellow to Orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 130.0 to 134.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 132 °C |
| Maximum Absorption Wavelength | 392 nm (MeOH) |
GHS
Related Laws:
Transport Information:
| HS Number | 2932990090 |
Application
Mollugin: A Crude Medicine Ingredient Contained in a Traditional Chinese Medical Plant, Rubia cordifolia L.
Mollugin is a naphthohydroquine originally isolated from the root of the traditional Chinese medical plant Rubia cordifolia L.1) It has been reported to have a variety of biological activities, including anti-inflammatory activity2,3), neuroprotective activity3), antitumor activity4,5), and inhibitory activity in arachidonic acid- and collagen-induced platelet aggregation.6) (The product is for research purpose only.)
References
- 1)An effective high-speed countercurrent chromatographic method for preparative isolation and purification of mollugin directly from the ethanol extract of the Chinese medicinal plant Rubia cordifolia
- 2)Anti-inflammatory action of mollugin and its synthetic derivatives in HT-29 human colonic epithelial cells is mediated through inhibition of NF-κB activation
- 3)Neuroprotective and anti-inflammatory effects of mollugin via up-regulation of heme oxygenase-1 in mouse hippocampal and microglial cells
- 4)Mollugin induces apoptosis in human Jurkat T cells through endoplasmic reticulum stress-mediated activation of JNK and caspase-12 and subsequent activation of mitochondria-dependent caspase cascade regulated by Bcl-xL
- 5)Mollugin induces tumor cell apoptosis and autophagy via the PI3K/AKT/mTOR/p70S6K and ERK signaling pathways
- 6)Antiplatelet constituents of Formosan Rubia alkane
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