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Published TCIMAIL newest issue No.201
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CAS RN: 113507-06-5 | Product Number: M3136
Moxidectin
×
Purity: >98.0%(N)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 250MG |
€54.00
|
2 | 15 |
|
|
| 1G |
€179.00
|
7 | 19 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
Supplemental Product Information:
This product has not been tested for potency and is guaranteed for chemical purity.
| Product Number | M3136 |
Purity / Analysis Method 
|
>98.0%(N) |
| Molecular Formula / Molecular Weight | C__3__7H__5__3NO__8 = 639.83 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (-20°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container
|
250MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 113507-06-5 |
| Reaxys Registry Number | 4649146 |
| PubChem Substance ID | 468592289 |
| Merck Index (14) | 6290 |
| MDL Number | MFCD00866560 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Melting point | 130.0 to 134.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 132 °C |
| Specific Rotation | 140° (C=1,CHCl3) |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. H410 : Very toxic to aquatic life with long lasting effects. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P391 : Collect spillage. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. |
Related Laws:
| RTECS# | PY5438800 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| HS Number | 2941900000 |
Application
Moxidectin: A Macrocyclic Lactone with Anthelmintic Activity
Moxidectin, a macrocyclic lactone, is an anthelmintic and a semisynthetic methoxime derivative of naturally occurring nemadectin. It is well known for the action against a broad range of animalparasites. The precise mechanism of action is unknown, but studies with nematodes suggest that moxidectin binds to glutamate-gated chloride channels (GluCl), gamma-aminobutyric acid (GABA) receptors and/or ATP-binding cassette (ABC) transporters, causing muscle paralysis and death of the parasite. (The product is for research purpose only.)
References
- Moxidectin: a review of chemistry, pharmacokinetics and use in horses (a review)
- Macrocyclic lactones in the treatment and control of parasitism in small companion animals (a review)
- Analysis of avermectin and moxidectin residues in milk by liquid chromatography-tandem mass spectrometry using an atmospheric pressure chemical ionization/atmospheric pressure photoionization source
- Determination of anthelmintic drug residues in milk using ultra high performance liquid chromatography-tandem mass spectrometry with rapid polarity switching
- Analytical profile of moxidectin (a review)
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