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Published TCIMAIL newest issue No.199
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CAS RN: 53-03-2 | Product Number: P1276
Prednisone
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Purity: >96.0%(HPLC)
Synonyms:
- 1,4-Pregnadiene-17α,21-diol-3,11,20-trione
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
€56.00
|
1 | ≥40 |
|
| 25G |
€179.00
|
Contact Us | 12 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | P1276 |
Purity / Analysis Method 
|
>96.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__1H__2__6O__5 = 358.43 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 53-03-2 |
| Reaxys Registry Number | 2065301 |
| PubChem Substance ID | 87575370 |
| SDBS (AIST Spectral DB) | 15643 |
| Merck Index (14) | 7722 |
| MDL Number | MFCD00003608 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 96.0 area% |
| Specific rotation [a]20/D | +165.0 to +175.0 deg(C=0.5, Dioxane) |
| Solubility in N,N-DMF | very faint turbidity |
| NMR | confirm to structure |
Properties (reference)
| Specific Rotation | 170° (C=0.5,Dioxane) |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H361 : Suspected of damaging fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
Related Laws:
| EC Number | 200-160-3 |
| RTECS# | TU4154100 |
Transport Information:
| HS Number | 2937210000 |
Application
Bacterial spore germinant research
Bacterial spores are more resistant to antibiotics and nutritional deficiencies than their vegetative cells and sometimes cause serious problems from the viewpoint of hygiene in clinical treatment and food processing.1) Spore persistence also plays a major role in the recurrence of infections after antibiotic treatment. Molecules that stimulate germination are termed “germinants”1) and the efficacy of germinant administration combined with antibiotics have been evaluated (for example, reports by N. Budi et al.2,3)). Prednisone has been reported to act as a germinant for Clostridium sordellii spores (EC50 = 241.6 μM) and as an inhibitor for Clostridium difficle spores (IC50 = 305.6 μM).4)
(The product is for research purpose only.)
(The product is for research purpose only.)
References
- 1) Germinants and Their Receptors in Clostridia
- 2) Omadacycline Compared to Vancomycin When Combined with Germinants To Disrupt the Life Cycle of Clostridioides difficile.
- 3) Efficacy of Omadacycline or Vancomycin Combined With Germinants for Preventing Clostridioides difficile Relapse in a Murine Model
- 4) Progesterone Analogs Influence Germination of Clostridium sordellii and Clostriduim difficile Spores In Vitro
- Clinical pharmacokinetics of prednisone and prednisolone (a review)
- Glucocorticoid use in acute lymphoblastic leukemia (a review)
- Rapid determination of corticosteroids in urine by combined solid phase microextraction/liquid chromatography/mass spectrometry
- Quantification of corticosteroids in human plasma by liquid chromatography-thermospray mass spectrometry using stable isotope dilution
- Identification of ten corticosteroids in human hair by liquid chromatography-ionspray mass spectrometry
Application
Prednisone: A Prodrug of Prednisolone which is an Adrenocortical Steroid Agent with Predominantly Glucocorticoid Properties
Prednisone is a prodrug of prednisolone [P0637] which is a synthetic adrenocortical steroid agent with predominantly glucocorticoid properties. Prednisone is also used for the treatment of a wide range of inflammatory and autoimmune conditions. (The product is for research purpose only.)
References
PubMed Literature
Documents
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Specifications
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