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Published TCIMAIL newest issue No.198
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CAS RN: 14221-01-3 | Product Number: T1350
Tetrakis(triphenylphosphine)palladium(0)
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Purity: >97.0%(T)
Synonyms:
- Pd(PPh3)4
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
€48.00
|
≥40 | ≥100 |
|
| 5G |
€130.00
|
36 | ≥100 |
|
| 25G |
€540.00
|
Contact Us | ≥100 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | T1350 |
Purity / Analysis Method 
|
>97.0%(T) |
| Molecular Formula / Molecular Weight | C__7__2H__6__0P__4Pd = 1,155.59 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (-20°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 14221-01-3 |
| Reaxys Registry Number | 11604118 |
| PubChem Substance ID | 87577117 |
| MDL Number | MFCD00010012 |
Specifications
| Appearance | Light yellow to Amber to Dark green powder to crystaline |
| Purity(Chelometric Titration) | 97.0 to 106.0 % |
| IR | confirm to structure |
Properties (reference)
| Melting Point | 115 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H413 : May cause long lasting harmful effects to aquatic life. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| EC Number | 238-086-9 |
Transport Information:
| HS Number | 2843909000 |
Application
TCI Practical Example: Suzuki-Miyaura Cross Coupling Using Pd(PPh3)4
Used Chemicals
Procedure
(3-Formylphenyl)boronic acid (480 mg, 3.2 mmol) and 4-chloro-3,5-dimethyl-phenol (500 mg, 3.2 mmol) and tetrakis(triphenylphosphine)palladium(0) (55 mg, 0.048 mmol, 1.5 mol%) were dissolved in degassed ethanol (20 mL). A solution of sodium carbonate (250 mg, 2.4 mmol) in water (5 mL) was added to the solution, and the mixture was stirred for 5 h at 75 °C. The reaction mixture was cooled to room temperature and filtered. The filtrate was concentrated, cooled Et2O (15 mL) was added and filtered to remove insoluble. The filtrate was concentrated to give the desired product as a pale yellow crystalline solid (506 mg, 2.24 mmol, 70%).
Experimenter's Comments
Ethanol was degassed by purging with N2.
The reaction mixture was monitored by TLC (hexane : ethyl acetate = 2 : 3, Rf = 0.8).
Analytical Data（4′-Hydroxy-2′,6′-dimethyl-[1,1′-biphenyl]-3-carbaldehyde）
1H NMR (400 MHz, CDCl3); δ 10.09 (s, 1H), 8.13 (s, 1H), 7.90 (t, J = 6.8 Hz, 2H), 7.65 (t, J = 7.6 Hz, 1H), 6.56 (s, 2H), 4.79 (s, 1H), 2.36 (s, 6H).
Lead Reference
- Suzuki Reaction for the Synthesis of New Derivatives of 4-Chloro-3,5-Dimethyl Phenol and their in vitro Antibacterial Screening
Application
Palladium-Catalyzed Three-Component Reaction for the Synthesis of Imidazolidinones
Typical Procedure: Once the Schlenk tube containing K2CO3 (55 mg, 0.40 mmol) is flamed, dried, and filled with argon, Pd(PPh3)4 (12 mg, 0.010 mmol), PMB-protected 2,3-allenylamine (37 mg, 0.20 mmol), iodobenzene (58 mg, 0.28 mmol), phenyl isocyanate (36 mg, 0.30 mmol), and CH3CN (4 mL) are added sequentially. The resulting solution is heated to and stirred at 70°C. When the reaction is completed as monitored by TLC, the solvent is evaporated under reduced pressure, and the residue is purified by chromatography on silica gel (petroleum ether : ethyl acetate = 7:1) to afford the corresponding imidazolidione (72 mg, Y. 96%) as an oil.
References
PubMed Literature
Documents
Product Articles
[TCI Practical Example] Suzuki-Miyaura Coupling of Diaminonaphthalene (dan)-Protected Bromophenylboronic Acid[Product Highlights] Enol Tosylate for Stereoretentive Cross Coupling Reactions
[Research Articles] Palladium-Catalyzed Three-Component Reaction for the Synthesis of Imidazolidinones
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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Other Documents
Related Products
Pd(PPh3)4 (HPMC encapsulated)
| Product # | R0304 |
| CAS RN | 14221-01-3 |
| Purity / Analysis Method: |