Trimethoprim

Reference

• 1) Natural and synthetic compounds such as trimethoprim behave as inhibitors of efflux in Gram-negative bacteria
  • L.J.V. Piddock, M.I. Garvey, M.M. Rahman, S. Gibbons, J. Antimicrob. Chemother. 2010, 65, 1215.


Application
Trimethoprim: A Synthetic Antibiotic Agent Inhibiting Dihydrofolate Reductase
Trimethoprim, a synthetic antibiotic agent, exerts antimicrobial activity by blocking the production of tetrahydrofolic acid from dihydrofolic acid by binding to and reversibly inhibiting the required enzyme, dihydrofolate reductase. Trimethoprim is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. In addition, some combination agents with the other antimicrobials (e.g.: sulphamethoxazole [S0361], daptomycin [D4229] and polymyxin B [P1923]) are widely used for the treatment of infections including MRSA infection. (The product is for research purpose only.)

References

• Trimethoprim: mechanisms of action, antimicrobial activity, bacterial resistance, pharmacokinetics, adverse reactions, and therapeutic indications (a review)
  • R. Gleckman, N. Blagg, D. W. Joubert, Pharmacotherapy 1981, 1, 14.
• Trimethoprim: a review of its antibacterial activity, pharmacokinetics and therapeutic use in urinary tract infections
  • R. N. Brogden, A. A. Carmine, R. C. Heel, T. M. Speight, G. S. Avery, Drugs 1982, 23, 405.
• Trimethoprim/sulfonamide combinations in the horse: A review
  • E. Van. Duijkeren, A .G. Vulto, A. S. J. P. A. M. Van Miert, J. Vet. Pharmacol. Ther. 1994, 17, 64.
• Trimethoprim and sulfonamide resistance (a review)
  • P. Huovinen, L. Sundstrom, G. Swedberg, O. Skold, Antimicrob. Agents Chemother. 1995, 39, 279.
• Evaluation of the novel combination of high-dose daptomycin plus trimethoprim-sulfamethoxazole against daptomycin-nonsusceptible methicillin-resistant Staphylococcus aureus using an in vitro pharmacokinetic/pharmacodynamic model of simulated endocardial vegetations
  • M. E. Steed, B. J. Werth, C. E. Ireland, M. J. Rybak, Antimicrob. Agents Chemother. 2012, 56, 5709.
• Quantification of veterinary antibiotics (sulfonamides and trimethoprim) in animal manure by liquid chromatography-mass spectrometry
  • M. Y. Haller, S. R. Müller, C. S. McArdell, A. C. Alder, M. J.-F Suter, J. Chromatogr. A 2002, 952, 111.


PubMed Literature