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Published TCIMAIL newest issue No.198
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CAS RN: 50-35-1 | Product Number: T2524
(±)-Thalidomide
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Purity: >98.0%(HPLC)(N)
Synonyms:
- N-(2,6-Dioxo-3-piperidinyl)phthalimide
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
€70.00
|
2 | 12 |
|
| 5G |
€225.00
|
1 | 14 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | T2524 |
Purity / Analysis Method 
|
>98.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | C__1__3H__1__0N__2O__4 = 258.23 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 50-35-1 |
| Reaxys Registry Number | 30233 |
| PubChem Substance ID | 253662357 |
| Merck Index (14) | 9255 |
| MDL Number | MFCD00153873 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
Properties (reference)
| Melting Point | 276 °C |
| Maximum Absorption Wavelength | 300 nm |
| Solubility in water | Insoluble |
| Degree of solubility in water | 60 mg/l 25 °C |
| Solubility (insoluble in) | Benzene, Chloroform, Ether |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. H312 : Harmful in contact with skin. H361 : Suspected of damaging fertility or the unborn child. |
| Precautionary Statements | P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water. Call a POISON CENTER/doctor if you feel unwell. |
Related Laws:
| EC Number | 200-031-1 |
| RTECS# | TI4375000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| HS Number | 2925199590 |
Application
Thalidomide: An Inhibitor of Angiogenesis
Thalidomide was originally used to treat morning sickness, but was banned as a human teratogen in the 1960s. In the 1990s, thalidomide has been discovered to have anti-inflammatory and anti-angiogenic properties, and is identified as an effective treatment for multiple myeloma. A recently approved amino analogue of thalidomide is pomalidomide [P2074]. (The product is for research purpose only.)
References
- Thalidomide selectively inhibits tumor necrosis factor α (TNF-α) production by stimulated human monocytes
- Thalidomide is an inhibitor of angiogenesis
- Antitumor activity of thalidomide in refractory multiple myeloma
- Timeline: The evolution of thalidomide and its IMiD derivatives as anticancer agents (a review)
- Multiple Myeloma (a review)
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