Tulobuterol Hydrochloride

Tulobuterol is a β₂-adrenergic receptor agonist to induce relaxation of airway smooth muscle cells. The mechanism of action is explained as follows. Occupation of β₂-adrenergic receptors by tulobuterol results in the activation of the adenylyl cyclase (AC), leading to an increase in intracellular cyclic AMP [A2381] and activation of protein kinase A (PKA). PKA phosphorylates Ca²⁺-ATPase, resulting in opening of Ca²⁺-activated K⁺ channels, decreasing intracellular Ca²⁺ concentration, and also decreased myosin light chain kinase (MLCK) activity. Tulobuterol transdermal patch as a controlled-release drug delivery system is used for medical purposes. (The product is for research purpose only.)