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Published TCIMAIL newest issue No.198
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CAS RN: 134308-13-7 | Product Number: T3856
Tolcapone
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Purity: >98.0%(HPLC)
Synonyms:
- 3,4-Dihydroxy-4'-methyl-5-nitrobenzophenone
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 50MG |
€106.00
|
Contact Us | 23 |
|
| 200MG |
€287.00
|
1 | 13 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | T3856 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__4H__1__1NO__5 = 273.24 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 134308-13-7 |
| Reaxys Registry Number | 8151577 |
| PubChem Substance ID | 468592985 |
| Merck Index (14) | 9508 |
| MDL Number | MFCD00866569 |
Specifications
| Appearance | White to Yellow to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 142.0 to 146.0 °C |
Properties (reference)
| Melting Point | 145 °C |
GHS
Related Laws:
| RTECS# | PC4952500 |
Transport Information:
| HS Number | 2914790090 |
Application
Tolcapone: A Selective and Reversible Inhibitor of Catechol-O-methyltransferase (COMT)
Tolcapone is a selective and reversible inhibitor of catechol-O-methyltransferase (COMT) which is one of several enzymes that degrade catecholamines (such as L-DOPA [D0600], dopamine [A0305], L-epinephrine [A0173], and norepinephrine [A0906]). COMT catalyzes the transfer of the methyl group of S-adenosyl-L-methionine to the phenolic group of substrates that contain a catechol structure including catecholamines. Tolcapone crosses the blood-brain barrier and can inhibit both peripheral and central COMT activity. Therefore, it has been suggested that tolcapone prolong the biological half-life of L-DOPA and the therapeutic effect of L-DOPA for Parkinson's disease patients. (The product is for research purpose only.)
References
- Effects of tolcapone, a novel catechol-O-methyltransferase inhibitor, on striatal metabolism of L-DOPA and dopamine in rats
- Catechol-O-methyltransferase inhibition improves set-shifting performance and elevates stimulated dopamine release in the rat prefrontal cortex
- Catechol-O-methyltransferase and its inhibitors in Parkinson's disease (a review)
Product Documents (Note: Some products will not have analytical charts available.)
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Specifications
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