Maintenance Notice (12:30 AM - 5:30 AM August 24, 2025): This website is scheduled to be unavailable due to maintenance. We appreciate your patience and understanding.
Published TCIMAIL newest issue No.198
Maximum quantity allowed is 999
Please select the quantity
Phosphatidylinositol 3-Kinase Inhibitor
No.164(January 2015)
PKB/Akt, a serine/threonine kinase, regulates many kinds of important cellular functions including metabolism, proliferation, survival, apoptosis, etc.1) The kinase is activated by phosphatidylinositol 3-kinase (PI3-k) pathway.1)
LY294002 (1) is a specific inhibitor of PI3-k.2) 1 blocks the PI3-k/Akt pathway inducing apoptosis in many types of tumor cells.3) 1 also suppresses self-renewal4) and proliferation5) of embryonic stem cells and enhances the generation of mouse induced pluripotent stem (iPS) cells.6)
References
- 1)PI3K-PKB/Akt pathway
- 2)A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
- 3)LY294002 and LY303511 sensitize tumor cells to drug-induced apoptosis via intracellular hydrogen peroxide production independent of the phosphoinositide 3-kinase-Akt pathway
- 4)Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling
- 5)Phosphoinositide 3-kinase inhibitor LY294002 but not serum withdrawal suppresses proliferation of murine embryonic stem cells
- 6)Rapamycin and other longevity-promoting compounds enhance the generation of mouse induced pluripotent stem cells
Related Compounds
The prices are subject to change without notice. Please confirm the newest price by our online catalog before placing an order.
In addition, sales products changes with areas. Please understand that a product is not available when the product details page is not displayed.
In addition, sales products changes with areas. Please understand that a product is not available when the product details page is not displayed.