Forskolin (1) is a diterpenoid from the Indian plant, Coleus forskolii.1)1 activates adenylate cyclase.2,3)1 induces differentiation of mesenchymal stem cells into neuron-like cells.4) Recently, 1 was utilized for establishing chemically induced pluripotent stem cells (iPSCs) as one of the chemical “substitutes” of Oct4, which is one of four transcription factors (Oct4, Klf4, Sox2, and c-Myc or Oct4, Sox2, Nanog, and Lin28).5)
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References
1)On the high value medicinal plant, Coleus forskohlii Briq
M. Paul, A. Radha, D. S. Kumar, Hygeia J. D. Med.2013, 5, 69.
2)Interactions of forskolin and adenylate cyclase. Effects on substrate kinetics and protection against inactivation by heat and N-ethylmaleimide
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