Glutathione peroxidase (EC1.11.1.9, GPx) is an enzyme related with anti-oxidation in mammal bodies.1) The enzyme consists of four sub-units and contains a selenium atom per subunit.2) The selenium atom exists in the enzyme as selenocysteine residue (Sec45*) and it is proposed that the residue forms the active center of the enzyme.3) The selenocysteine residue forms a catalytic triad with two other amino acid residues, Gln79* and Trp153*.3) Based on the knowledge, small organic molecules containing selenium have been designed as a mimic of the enzyme.3) Ebselen (1) is one of such seleno-molecules and possesses GPx like activity.4,5) Therefore, 1 works as an anti-oxidant.6)
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Published TCIMAIL newest issue No.198
