Maintenance Notice (12:30 AM - 5:30 AM August 24, 2025): This website is scheduled to be unavailable due to maintenance. We appreciate your patience and understanding.
Published TCIMAIL newest issue No.198
Maximum quantity allowed is 999
Please select the quantity
Protein Kinase Inhibitor: Indirubin
No.175(October 2017)
Indirubin (1) is an inhibitor of protein kinases (Table).1,2) According to a crystal structure study of CDK2 in complexation with indirubin derivatives has shown that 1 interacts with the ATP-binding site of the kinase.1) 1 also was reported to have high binding affinity with the aryl hydrocarbon receptor (AhR).3)
In DNCB-induced mice, 1 inhibited allergic contact dermatitis by regulating T helper mediated immune system.4)
CDK: cyclin-dependent kinase
DNCB: 1-chloro-2,4-dinitrobenzene
DNCB: 1-chloro-2,4-dinitrobenzene
References
- 1)Indirubin, the active constituent of a chinese antileukaemia medicine, inhibits cyclin-dependent kinases
- 2)Indirubins inhibit glycogen synthase kinase-3β and CDK5/P25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer’s disease
- 3)Indirubin and indigo are potent aryl hydrocarbon receptor ligands present in human urine
- 4)Indirubin, a purple 3,2- bisindole, inhibited allergic contact dermatitis via regulating T helper (Th)-mediated immune system in DNCB-induced model
The prices are subject to change without notice. Please confirm the newest price by our online catalog before placing an order.
In addition, sales products changes with areas. Please understand that a product is not available when the product details page is not displayed.
In addition, sales products changes with areas. Please understand that a product is not available when the product details page is not displayed.