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FGFR/VEGFR Tyrosine Kinase Inhibitor
No.177(April 2018)
PD173074 (1) inhibits the tyrosine kinase activities of the fibroblast growth factor receptor (FGFR) and vascular endothelial growth factor receptor (VEGFR) (Table 1).1) The inhibitory manner of 1 is ATP-competitive and the inhibitory constants (Ki) of 1 to FGFR1 and its cytoplasmic domain are 45.2±4.8 nM and 36.4±3.6 nM, respectively.
1 also inhibits the differentiation of mouse and human embryo stem cells2,3) and human induced pluripotent stem cells.4)
Table 1. Inhibitory activity of PD173074
This product is for research purpose only.
References
- 1)Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain
- 2)The ground state of embryonic stem cell self-renewal
- 3)Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs
- 4)Virus-free induction of pluripotency and subsequent excision of reprogramming factors
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