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Published TCIMAIL newest issue No.198
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OCT4 Activators
OCT4 is a master regulator of the induction and maintenance of cellular pluripotency, and has crucial roles in early stages of cell differentiation.1) OAC-2 (1) and OAC-3 (2) activate expression of OCT4.2) These OCT4-activating compounds were identified using high-throughput screening by Li et al. and were found to enhance reprogramming efficiency from embryonic fibroblasts to induced pluripotent stem cells (iPSCs).
References
- 1) Structural and mechanistic insights into nuclear transport and delivery of the criticalpluripotency factor Oct4 to DNA
- 2) Identification of Oct4-activating compounds that enhance reprogramming efficiency
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