盲盒好礼，精彩继续 | 轻松扫码查看产品文档 | TCIMAIL No.198 已上新 | TCI试剂——品质可靠，值得信赖
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CAS RN: 893413-42-8 | 产品编码: C3461
(6-Chloro-1H-benzotriazol-1-yloxy)tripyrrolidinophosphonium Hexafluorophosphate
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| 规格 | 单价 | 上海 | 天津 | 日本* | 数量 |
库存详情
|
|---|---|---|---|---|---|---|
| 5G |
¥190.00
|
4 | 1 | 21 |
|
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* 对于可分装产品，11:30前的订单，当天发货；11:30后的订单，隔天发货。
* 如需大包装，请点击“大包装询价”按钮（对于某些产品我们无法提供大包装）。
* TCI会经常复审储藏条件以对其进行优化，请以在线目录为准，敬请留意。
* 更多信息，请联系营业部：021-67121386 / Sales-CN@TCIchemicals.com 。任何货期、规格或包装方面的需求，请联系我们 。
* 无具体发货日期的情况，如：显示“8个工作日后发货”，将在您订购日起的8个工作日后发货。
* 我们将以最优方式从上海/天津两大仓库发货。国内库存不足，需两周左右向日本总部调货。
* 对于可分装产品，11:30前的订单，当天发货；11:30后的订单，隔天发货。
* 如需大包装，请点击“大包装询价”按钮（对于某些产品我们无法提供大包装）。
* TCI会经常复审储藏条件以对其进行优化，请以在线目录为准，敬请留意。
* 更多信息，请联系营业部：021-67121386 / Sales-CN@TCIchemicals.com 。任何货期、规格或包装方面的需求，请联系我们 。
技术规格
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 173 °C(dec.) |
GHS
| 象形图 |
|
| 信号词 | 警告 |
| 危险性说明 | H315 : 造成皮肤刺激。 H319 : 造成严重眼刺激。 |
| 防范说明 | P264 : 作业后彻底清洗皮肤。 P280 : 戴防护手套/戴防护眼罩/戴防护面具。 P302 + P352 : 如皮肤沾染：用水充分清洗。 P337 + P313 : 如仍觉眼刺激：求医/就诊。 P305 + P351 + P338 : 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P362+P364 : 脱掉沾污的衣服，清洗后方可重新使用。 P332 + P313 : 如发生皮肤刺激：求医/就诊。 |
相关法规
| 新化学物质备案回执号 | B1A232214718 |
运输信息
| 监管条件代码(*) |
应用
Condensing Agent
Experimental procedure:
1 (0.5 g, 2.75 mmol) is dissolved in CH2Cl2 (5 mL). 2 (2.2 g, 5.5 mmol), DIEA (1.9 mL, 1.1 mmol), and TPTDP (3.057 g, 5.5 mmol) are dissolved in CH2Cl2 (5 mL). After 2 is dissolved, it is added to the solution of 1 and stirred overnight. The mixture is concentrated under reduced pressure. The methyl ester is removed using 1 mol/L LiOH (30 mL)/MeOH (70 mL) for 4 h. The mixture is acidified by the addition of 3 mol/L HCl (30 mL). MeOH is then removed by evaporation. Ethyl acetate (50 mL) and saturated NaCl (100 mL) is added, followed by extraction 4 times with ethyl acetate (50mL). The organic fractions are combined and the ethyl acetate is concentrated under reduced pressure. The crude is purified by RP-HPLC (CH3CN:H2O:TFA) to give 3 as a white solid.
1 (0.5 g, 2.75 mmol) is dissolved in CH2Cl2 (5 mL). 2 (2.2 g, 5.5 mmol), DIEA (1.9 mL, 1.1 mmol), and TPTDP (3.057 g, 5.5 mmol) are dissolved in CH2Cl2 (5 mL). After 2 is dissolved, it is added to the solution of 1 and stirred overnight. The mixture is concentrated under reduced pressure. The methyl ester is removed using 1 mol/L LiOH (30 mL)/MeOH (70 mL) for 4 h. The mixture is acidified by the addition of 3 mol/L HCl (30 mL). MeOH is then removed by evaporation. Ethyl acetate (50 mL) and saturated NaCl (100 mL) is added, followed by extraction 4 times with ethyl acetate (50mL). The organic fractions are combined and the ethyl acetate is concentrated under reduced pressure. The crude is purified by RP-HPLC (CH3CN:H2O:TFA) to give 3 as a white solid.
References
- Small Molecule Mimetics of an HIV-1 gp41 Fusion Intermediate as Vaccine Leads
参考文献