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CAS RN: 2646-38-0 | 产品编码: S0941
Sodium Chenodeoxycholate
规格 | 单价 | 上海 | 天津 | 日本* | 数量 |
---|---|---|---|---|---|
200MG |
¥140.00
|
4 | 2 | 6 |
|
1G |
¥490.00
|
4 | 联系我们 | 10 |
|
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* 更多信息,请联系营业部:021-67121386 / Sales-CN@TCIchemicals.com 。任何货期、规格或包装方面的需求,请联系我们 。
* 对于可分装产品,11:30前的订单,当天发货;11:30后的订单,隔天发货。
* 如需大包装,请点击“大包装询价”按钮(对于某些产品我们无法提供大包装)。
* TCI会经常复审储藏条件以对其进行优化,请以在线目录为准,敬请留意。
* 更多信息,请联系营业部:021-67121386 / Sales-CN@TCIchemicals.com 。任何货期、规格或包装方面的需求,请联系我们 。
技术规格
Appearance | White to Almost white powder to crystal |
Purity(GC) | min. 98.0 % |
Purity(Nonaqueous Titration) | min. 96.0 % |
物性(参考值)
熔点 | 298 °C(dec.) |
GHS
象形图 |
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信号词 | 警告 |
危险性说明 | H302 : 吞咽有害。 |
防范说明 | P501 : 将内装物/容器送到批准的废物处理厂处理。 P270 : 使用本产品时不要进食、饮水或吸烟。 P264 : 作业后彻底清洗皮肤。 P301 + P312 + P330 : 如误吞咽:如感觉不适,呼叫急救中心/医生。漱口。 |
相关法规
RTECS# | FZ2231000 |
新化学物质备案回执号 | B1A412215756 |
运输信息
监管条件代码(*) |
应用
Chenodeoxycholic Acid: A Naturally Occurring Bile Acid Having Suppressing Effects of Cholesterol and Cholic Acid Synthesis
Sodium chenodeoxycholate, a sodium salt of chenodeoxycholic acid, is a naturally occurring bile acid. Sodium chenodeoxycholate inhibits HMG-CoA-reductase and cholesterol-7α-hydroxylase, which are the rate-limiting step enzyme in cholesterol [C0318] and cholic acid [C0324] synthesis, respectively. Therefore, sodium chenodeoxycholate suppresses hepatic synthesis of both cholesterol and cholic acid, gradually replacing chenodeoxycholic acid in an expanded bile acid pool. In clinical use, these actions would contribute to gradual dissolution of cholesterol gallstones. (The product is for research purpose only.)
References
- Induced alterations in the rate-limiting enzymes of hepatic cholesterol and bile acid synthesis in the hamster.
- The effect of chenodeoxycholic acid (CDCA) on cholesterol absorption
- Chenodeoxycholic acid: a review of its pharmacological properties and therapeutic use
- Detoxification of lithocholic acid, a toxic bile acid: relevance to drug hepatotoxicity (a review)
参考文献