OCT4 Activators

OCT4 is a master regulator of the induction and maintenance of cellular pluripotency, and has crucial roles in early stages of cell differentiation.¹⁾ OAC-2 (1) and OAC-3 (2) activate expression of OCT4.²⁾ These OCT4-activating compounds were identified using high-throughput screening by Li et al. and were found to enhance reprogramming efficiency from embryonic fibroblasts to induced pluripotent stem cells (iPSCs).

References

• 1) Structural and mechanistic insights into nuclear transport and delivery of the criticalpluripotency factor Oct4 to DNA
  • T. Okuyama, R. Yamagishi, J. Shimada, M. Ikeda, Y. Maruoka, H. Kaneko, J. Biomol. Struct. Dyn. 2018, 36, 767.
• 2) Identification of Oct4-activating compounds that enhance reprogramming efficiency
  • W. Li, E Tian, Z.-X. Chen, G. Sun, P. Ye, S. Yang, D. Lu, J. Xie, T.-V. Ho, W. M. Tsark, C. Wang, D. A. Horne, A. D. Riggs, M. L. R. Yip, Y. Shi, Proc. Natl. Acad. Sci. USA 2012 109, 20853.

Related Product

O0490

OAC-1

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