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CAS RN: 38819-10-2 | Product Number: A2739

9-β-D-Arabinofuranosylguanine


Purity: >98.0%(HPLC)
Synonyms:
  • Ara-G
  • Guanine 9-β-D-Arabinofuranoside
Documents:
10MG
€15.00
1   18  
50MG
€37.00
1   14  

*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).


Note:

Previously this product had been labeled as a hydrate form both in product name and molecular formula. The hydrate form had no exclusive CAS RN and used to share the same CAS RN as the anhydrous form.
To avoid any misleading information and since moisture in product is considered as an impurity, we have decided to remove the term 'Hydrate' from product name and 'xH2O' from the molecular formula for such products.
Please use it at ease since there is no difference in product quality, even if you see the previous indications on a part of label.

Product Number A2739
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__1__0H__1__3N__5O__5 = 283.24  
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Condition to Avoid Heat Sensitive
CAS RN 38819-10-2
Reaxys Registry Number 1225954
PubChem Substance ID 253662300
MDL Number

MFCD00065486

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Elemental analysis(Nitrogen) 24.00% to 25.50% (calcd.on anh.substance)
Water 4.0 to 7.0 %
Properties (reference)
Melting Point 225 °C
Maximum Absorption Wavelength 252 nm
GHS
Related Laws:
RTECS# MF8301000
Transport Information:
HS Number 2934999090
Application
Ara-G: An Inhibitor of DNA Replication in T-Leukemic Cells

Arabinosylguanine (ara-G) is triphosphorylated by multiple kinases intracellularly to the active nucleotide, ara-GTP, which inhibits the DNA replication in T-leukemic cells. Ara-G is used for the treatment of T-cell acute lymphoblastic leukemia (T-ALL) or T-cell lymphoblastic lymphoma (T-LBL). From the 2000s, nelarabine (the 6-methoxy pro-drug of ara-G) have been introduced and used for the treatment of T-All and T-LBL. In organic synthesis, ara-G is used as an intermediate for the synthesis of guanosine analogs. (The product is for research purpose only.)

References


PubMed Literature


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