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CAS RN: 75-77-4 | Product Number: C0306

Chlorotrimethylsilane


Purity: >98.0%(GC)
Synonyms:
  • Trimethylchlorosilane
  • Trimethylsilyl Chloride
  • TMCS
  • TMS-Cl
Documents:
25ML
€15.00
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100ML
€19.00
2   ≥20 
500ML
€43.00
Contact Us ≥20 

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Product Number C0306
Purity / Analysis Method >98.0%(GC)
Molecular Formula / Molecular Weight C__3H__9ClSi = 108.64  
Physical State (20 deg.C) Liquid
Store Under Inert Gas Store under inert gas
Condition to Avoid Moisture Sensitive
CAS RN 75-77-4
Reaxys Registry Number 1209232
PubChem Substance ID 87565458
SDBS (AIST Spectral DB) 10585
MDL Number

MFCD00000502

Specifications
Appearance Colorless to Light yellow to Light orange clear liquid
Purity(GC) min. 98.0 %
Properties (reference)
Melting Point -58 °C
Boiling Point 57 °C
Flash point -28 °C
Specific Gravity (20/20) 0.86
Refractive Index 1.39
Solubility (soluble in) Ether,Benzene
GHS
Pictogram Pictogram Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H301 + H331 : Toxic if swallowed or if inhaled.
H312 : Harmful in contact with skin.
H314 : Causes severe skin burns and eye damage.
H371 : May cause damage to organs.
H225 : Highly flammable liquid and vapour.
H290 : May be corrosive to metals.
Precautionary Statements P260 : Do not breathe dust/ fume/ gas/ mist/ vapours/ spray.
P210 : Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P370 + P378 : In case of fire: Use dry sand, dry chemical or alcohol-resistant foam to extinguish.
P303 + P361 + P353 : IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor.
P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor.
P403 + P233 : Store in a well-ventilated place. Keep container tightly closed.
Related Laws:
EC Number 200-900-5
RTECS# VV2710000
Transport Information:
UN Number UN1298
Class 3 / 8
Packing Group II
HS Number 2931399090
Application
Acetylation of Alcohols using Acetylating Reagents and Acid Catalysts
References

1)A Simple Method for the Esterification of Carboxylic Acids Using Chlorosilanes

R. Nakao, K. Oka, T. Fukumoto, Bull. Chem. Soc. Jpn. 1981, 54, 1267.

2)Protection for the Hydroxyl Group, Including 1,2- and 1,3-Diols

P. G. M. Wuts, in Greene’s Protective Groups in Organic Synthesis, 5th ed., ed. by P. G. M. Wuts, John Wiley & Sons, Inc., Hoboken, New Jersey, 2014, Chap. 2, 17.


Application
Trimethylsilylation of Alcohols using TMS Reagents
References

Protection for the Hydroxyl Group, Including 1,2- and 1,3-Diols

P. G. M. Wuts, in Greene’s Protective Groups in Organic Synthesis, 5th ed., ed. by P. G. M. Wuts, John Wiley & Sons, Inc., Hoboken, New Jersey, 2014, Chap. 2, 17.


Application
Mono-TMS Protection of Diols using TMS Chloride and HMDS
References

Protection for the Hydroxyl Group, Including 1,2- and 1,3-Diols

P. G. M. Wuts, in Greene’s Protective Groups in Organic Synthesis, 5th ed., ed. by P. G. M. Wuts, John Wiley & Sons, Inc., Hoboken, New Jersey, 2014, Chap. 2, 17.


Application
SMe Cleavage/Acetylation of MTM(Methylthiomethyl) Groups using Chlorotrimethylsilane
References

Protection for the Hydroxyl Group, Including 1,2- and 1,3-Diols

P. G. M. Wuts, in Greene’s Protective Groups in Organic Synthesis, 5th ed., ed. by P. G. M. Wuts, John Wiley & Sons, Inc., Hoboken, New Jersey, 2014, Chap. 2, 17.


Application
Deprotection of MOM Groups using Chlorotrimethylsilane
References

Protection for the Hydroxyl Group, Including 1,2- and 1,3-Diols

P. G. M. Wuts, in Greene’s Protective Groups in Organic Synthesis, 5th ed., ed. by P. G. M. Wuts, John Wiley & Sons, Inc., Hoboken, New Jersey, 2014, Chap. 2, 17.


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