Maximum quantity allowed is 999
CAS RN: 102691-36-1 | Product Number: C2228
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|Purity / Analysis Method||>95.0%(GC)(T)|
|Molecular Formula / Molecular Weight||C__1__5H__3__2N__3OP = 301.41|
|Physical State (20 deg.C)||Liquid|
|Store Under Inert Gas||Store under inert gas|
|Condition to Avoid||Air Sensitive,Moisture Sensitive,Heat Sensitive|
|Reaxys Registry Number||3590103|
|PubChem Substance ID||87560237|
|Appearance||Colorless to Light orange to Yellow clear liquid|
|Purity(GC)||min. 95.0 %|
|Purity(Nonaqueous Titration)||min. 95.0 %|
|Flash point||60 °C|
|Specific Gravity (20/20)||0.95|
|Hazard Statements||H302 : Harmful if swallowed.
H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
H226 : Flammable liquid and vapour.
|Precautionary Statements||P210 : Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P370 + P378 : In case of fire: Use dry sand, dry chemical or alcohol-resistant foam to extinguish.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P303 + P361 + P353 : IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water.
- 2-Cyanoethyl N,N,N',N'-Tetraisopropylphosphordiamidite [C2228]
To an acetonitrile (1 mL) solution of 2-cyanoethyl N,N,N',N'-tetraisopropylphosphordiamidite (0.21 g, 0.69 mmol) and 1H-tetrazole (40 mg, 0.58 mmol) were added a DMF solution of 1 (0.20 g, 0.58 mmol) at room temperature. The reaction mixture was stirred overnight at room temperature, then diluted with TBME and washed with water, DMF:H2O (1:1) solution, H2O, and brine. The organic layer was concentrated under reduced pressure. The resulting crude product was purified by column chromatography (hexane:ethyl acetate:triethylamine = 1:2:0.03 on silica gel) to give 2 as a white powder (0.23 g, 72% yield).
The reaction mixtures were monitored by LCMS.
1H NMR (400 MHz, DMSO-d6); δ 11.36 (brs, 1H), 8.05-7.96 (m, 2H), 7.73-7.64 (m, 1H), 7.59-7.51 (m, 2H), 7.45-7.37 (m, 1H), 6.25-6.17 (m, 1H), 4.72-4.62 (m, 1H), 4.62-4.52 (m, 1H), 4.51-4.38 (m, 1H), 4.32-4.15 (m, 1H), 3.84-3.66 (m, 2H), 3.66-3.51 (m, 2H), 2.84-2.73 (m, 2H), 2.47-2.22 (m, 2H), 1.67-1.53 (m, 3H), 1.27-1.03 (m, 12H).
13C NMR (101 MHz, DMSO-d6); δ 165.5, 163.6, 150.4, 135.8, 133.7, 129.3 (3C), 128.9 (2C), 119.0, 109.9, 84.1, 82.8, 72.8, 64.9, 58.3 (2C), 42.7, 37.7, 24.3 (4C), 19.8, 11.9.
31P NMR (162 MHz, DMSO-d6); δ 147.89.
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