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CAS RN: 78628-80-5 | Product Number: D2049
Terbinafine Hydrochloride
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Purity: >98.0%(T)(HPLC)
Synonyms:
- trans-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthylmethylamine Hydrochloride
- (E)-N,6,6-Trimethyl-N-(naphthalen-1-ylmethyl)hept-2-en-4-yn-1-amine Hydrochloride
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 1G |
51,00 €
|
Contact Us | ≥80 |
|
|
| 5G |
195,00 €
|
1 | 35 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | D2049 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__1H__2__5N·HCl = 327.90 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 78628-80-5 |
| Related CAS RN
|
91161-71-6 |
| Reaxys Registry Number | 5660449 |
| PubChem Substance ID | 87568500 |
| Merck Index (14) | 9156 |
| MDL Number | MFCD00145430 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 214 °C |
GHS
Related Laws:
| RTECS# | QJ8600100 |
Transport Information:
| HS Number | 2921490090 |
Application
Terbinafine Hydrochloride: A Potent Non-Competitive Inhibitor of Squalene Epoxidase
Terbinafine [T3677] and its hydrochloride, allylamine antifungals, are potent non-competitive inhibitors of fungal squalene epoxidase, a key enzyme in ergosterol biosynthesis. Ergosterol is an essential component of fungal cell membrane, and terbinafine inhibits ergosterol synthesis at the stage of squalene epoxidation. This results in fungal cell death primarily due to the increased membrane permeability mediated by the accumulation of high concentrations of squalene but not due to ergosterol deficiency. (The product is for research purpose only.)
References
- Experimental chemotherapy with combinations of ergosterol biosynthesis inhibitors in murine models of Chagas' disease
- Therapeutic efficacy of topically applied KP-103 against experimental tinea unguium in guinea pigs in comparison with amorolfine and terbinafine
- Fungicidal Activity Plus Reservoir Effect Allow Short Treatment Courses with Terbinafine in Tinea pedis (a review)
- Tinea capitis Dermatophytes: Susceptibility to Antifungal Drugs Tested in vitro and in vivo
- High-performance liquid chromatographic assay of terbinafine hydrochloride in tablets and creams
- Quantitative analysis of terbinafine (Lamisil) in human and minipig plasma by liquid chromatography tandem mass spectrometry
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