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Published TCIMAIL newest issue No.201
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CAS RN: 700874-72-2 | Product Number: G0639
Galunisertib
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Purity: >98.0%(T)(HPLC)
Synonyms:
- LY-2157299
- 4-[2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]quinoline-6-carboxamide
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 100MG |
€298.00
|
Contact Us | 7 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | G0639 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__2H__1__9N__5O = 369.43 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 700874-72-2 |
| Reaxys Registry Number | 14275134 |
| MDL Number | MFCD12923319 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 246.0 to 250.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 248 °C |
GHS
Related Laws:
Transport Information:
| HS Number | 2933499090 |
Application
Galunisertib: An Oral and Selective TGF-β Receptor Type I (TGF-βR type I) Kinase Inhibitor
Transforming growth factor-beta (TGF-β) signaling regulates a wide range of biological processes. It has been reported that TGF-β plays an important role in tumorigenesis and migration of cancer cells.1) Galunisertib (LY2157299 monohydrate) is an oral and selective TGF-β receptor type I (TGF-βR type I) kinase inhibitor, and it has been used to study the role of TGF-β signaling in chemotherapy-induced expansion of cancer stem-like cells.2,3) (The product is for research use only.)
References
- 1) TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis
- 2) Clinical development of galunisertib (LY2157299 monohydrate), a small molecule inhibitor of transforming growth factor-beta signaling pathway
- 3) Targeting the TGFβ pathway with galunisertib, a TGFβRI small molecule inhibitor, promotes anti-tumor immunity leading to durable, complete responses, as monotherapy and in combination with checkpoint blockade
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