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CAS RN: 910110-45-1 | Product Number: H1407
(2S)-N-[(1S)-1-(Hydroxydiphenylmethyl)-3-methylbutyl]-2-pyrrolidinecarboxamide
![Thumbnail of (2S)-N-[(1S)-1-(Hydroxydiphenylmethyl)-3-methylbutyl]-2-pyrrolidinecarboxamide](/medias/H1407.jpg?context=bWFzdGVyfHJvb3R8MTc2MTN8aW1hZ2UvanBlZ3xhR0UxTDJobVlpODRPVE0xTkRrME9UYzFOVEU0TDBneE5EQTNMbXB3Wnd8MmU0YzA2ODM0MDg3MTdkZmMzYTk1MWQ0NDJlOWQ1ZjA0ZjkxM2E2NTE3ODg1YmQ0NzIzM2Q4NzcxMjYzNTI4Yw "(2S)-N-[(1S)-1-(Hydroxydiphenylmethyl)-3-methylbutyl]-2-pyrrolidinecarboxamide")
![Chemical Structure of (2S)-N-[(1S)-1-(Hydroxydiphenylmethyl)-3-methylbutyl]-2-pyrrolidinecarboxamide](/medias/H1407.jpg?context=bWFzdGVyfHJvb3R8NTg5NTB8aW1hZ2UvanBlZ3xhRFJsTDJoaFlpODRPVEl5TURNMk1EUXpPREEyTDBneE5EQTNMbXB3Wnd8MTUxMjNjMjM3ZTU4ZTVjNzdiZmE1MjE4OGI4YzkyNjgwMmU1NGVkZWI4NThjNmFmZWNmZWExNmZjMzE2NGQ2Yg "(2S)-N-[(1S)-1-(Hydroxydiphenylmethyl)-3-methylbutyl]-2-pyrrolidinecarboxamide")
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![(2S)-N-[(1S)-1-(Hydroxydiphenylmethyl)-3-methylbutyl]-2-pyrrolidinecarboxamide](/_ui/responsive/theme-tci/images/missing_product_zoom.webp "(2S)-N-[(1S)-1-(Hydroxydiphenylmethyl)-3-methylbutyl]-2-pyrrolidinecarboxamide")
Purity: >98.0%(T)(HPLC)
Synonyms:
- (S)-N-[(S)-1-Hydroxy-4-methyl-1,1-diphenylpentan-2-yl]pyrrolidine-2-carboxamide
- N-[(1S)-1-(Hydroxydiphenylmethyl)-3-methylbutyl]-L-prolinamide
- Singh's Catalyst
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 200MG |
62,00 €
|
2 | 3 |
|
|
| 1G |
216,00 €
|
4 | Contact Us |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | H1407 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__3H__3__0N__2O__2 = 366.51 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 910110-45-1 |
| Reaxys Registry Number | 10473304 |
| PubChem Substance ID | 253661520 |
| MDL Number | MFCD22200506 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 191.0 to 195.0 °C |
| Specific rotation [a]20/D | -46.0 to -49.0 deg(C=1, CHCl3) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 193 °C |
| Specific Rotation | -47° (C=1,CHCl3) |
| Solubility (soluble in) | Methanol |
GHS
Related Laws:
Transport Information:
| HS Number | 2933998090 |
Application
An Efficient Chiral Organocatalyst for the Cross-aldol Reaction of Aliphatic Ketones with Aldehydes
An aldehyde (0.5 mmol) is added to a mixture of ketone (2 mmol) and Singh's catalyst (0.5 mol %) in brine (0.5 mL) at -5 °C. The reaction mixture is stirred and the progress of the reaction is monitored by TLC. After reaction is over, the reaction mixture is diluted with EtOAc (10 mL). The organic layer is separated and dried over anhydrous Na2SO4. It is purified over silica gel by column chromatography to give the aldol product.
References
- Highly Efficient Small Organic Molecules for Enantioselective Direct Aldol Reaction in Organic and Aqueous Media
- Highly Enantioselective Organocatalytic Direct Aldol Reaction in an Aqueous Medium
- Highly Enantioselective Direct Aldol Reaction Catalyzed by Organic Molecules
- Enantioselective Aldol Reactions of Aliphatic Aldehydes with Singh’s Catalyst
PubMed Literature
Product Articles
[Product Highlights] An Efficient Chiral Organocatalyst for the Cross-aldol Reaction of Aliphatic Ketones with AldehydesProduct Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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