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Published TCIMAIL newest issue No.201
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CAS RN: 72432-03-2 | Product Number: M2302
Miglitol
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Purity: >98.0%(GC)(T)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 1G |
71,00 €
|
2 | 14 |
|
|
| 5G |
247,00 €
|
1 | 6 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | M2302 |
Purity / Analysis Method 
|
>98.0%(GC)(T) |
| Molecular Formula / Molecular Weight | C__8H__1__7NO__5 = 207.23 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 72432-03-2 |
| Reaxys Registry Number | 5329949 |
| PubChem Substance ID | 160871160 |
| Merck Index (14) | 6187 |
| MDL Number | MFCD00867240 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 98.0 % |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 144.0 to 148.0 °C |
| Specific rotation [a]20/D | -7.0 to -9.0 deg(C=0.5、H2O) |
Properties (reference)
| Melting Point | 146 °C |
| Specific Rotation | -8° (C=0.5,H2O) |
| Solubility in water | Soluble |
GHS
Related Laws:
| EC Number | 276-661-6 |
| RTECS# | TN4350170 |
Transport Information:
| HS Number | 2933399999 |
Application
Miglitol: A Pseudo-Monosaccharide α-Glucosidase Inhibitor
Miglitol is a pseudo-monosaccharide α-glucosidase inhibitor. α-Glucosidase (also called maltase) is an enzyme, and catalyzes the hydrolysis of terminal 1,4-linked α-glucose residues of oligosaccharides and disaccharides to a single α-glucose molecule. Miglitol lowers blood sugar by inhibiting the enzyme α-glucosidase in the gastrointestinal tract, resulting in delayed glucose absorption. Recently, it is reported that miglitol suppresses the expression of interleukins which are a group of cytokines that are seen to be expressed by white blood cells (leukocytes). (The product is for research purpose only.)
References
- Pharmacokinetics of miglitol. Absorption, distribution, metabolism, and excretion following administration to rats, dogs, and man
- Miglitol: a review of its therapeutic potential in type 2 diabetes mellitus (a review)
- Miglitol suppresses the postprandial increase in interleukin 6 and enhances active glucagon-like peptide 1 secretion in viscerally obese subjects
- The α-glucosidase inhibitor miglitol decreases glucose fluctuations and inflammatory cytokine gene expression in peripheral leukocytes of Japanese patients with type 2 diabetes mellitus
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