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Published TCIMAIL newest issue No.201
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CAS RN: 128794-94-5 | Product Number: M2387
Mycophenolate Mofetil
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 2-(4-Morpholinyl)ethyl (E)-6-(1,3-Dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoate
- (E)-6-(1,3-Dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic Acid 2-(4-Morpholinyl)ethyl Ester
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 100MG |
18,00 €
|
1 | 16 |
|
|
| 1G |
114,00 €
|
2 | ≥100 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | M2387 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__3H__3__1NO__7 = 433.50 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container
|
100MG-Glass Bottle with Plastic Insert (View image), 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 128794-94-5 |
| Reaxys Registry Number | 14419508 |
| PubChem Substance ID | 253661600 |
| Merck Index (14) | 6327 |
| MDL Number | MFCD00867568 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 94.0 to 98.0 °C |
Properties (reference)
| Melting Point | 96 °C |
| Solubility in water | Insoluble |
| Degree of solubility in water | 43 mg/l |
| Solubility (soluble in) | Methanol |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H302 : Harmful if swallowed. H360 : May damage fertility or the unborn child. H351 : Suspected of causing cancer. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. |
Related Laws:
| RTECS# | MP7746700 |
Transport Information:
| HS Number | 2934999090 |
Application
Mycophenolate mofetil (MMF): An Inhibitor of Inosine Monophosphate Dehydrogenase (IMPDH), Needed for the Growth of T Cells and B Cells
Mycophenolate mofetil (abbrev: MMF) is an ester prodrug of the active immunosuppressant mycophenolic acid (MPA)[M2216] . MPA is a noncompetitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH), an important enzyme in the de novo synthesis of guanosine nucleotides in T and B lymphocytes. MMF is a widely used component of immunosuppressive regimens in organ transplantation. (The product is for research purpose only.)
References
- Mycophenolate mofetil: A review of its pharmacodynamic and pharmacokinetic properties and clinical efficacy in renal transplantation
- Mycophenolate mofetil (a review)
- Mycophenolate mofetil and its mechanisms of action (a review)
- Regulatory T cells induced by 1α,25-dihydroxyvitamin D3 and mycophenolate mofetil treatment mediate transplantation tolerance
- Mycophenolate mofetil in organ transplantation: focus on metabolism, safety and tolerability (a review)
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