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Published TCIMAIL newest issue No.198
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CAS RN: 129618-40-2 | Product Number: N0922
Nevirapine
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Purity: >98.0%(GC)
Synonyms:
- 11-Cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 200MG |
€19.00
|
1 | ≥60 |
|
| 1G |
€51.00
|
Contact Us | 33 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
Supplemental Product Information:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| Product Number | N0922 |
| Purity / Analysis Method | >98.0%(GC) |
| Molecular Formula / Molecular Weight | C__1__5H__1__4N__4O = 266.30 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 200MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 129618-40-2 |
| Reaxys Registry Number | 4757598 |
| PubChem Substance ID | 160871291 |
| Merck Index (14) | 6490 |
| MDL Number | MFCD00866928 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(GC) | min. 98.0 % |
| Purity(Nonaqueous Titration) | min. 97.0 % |
| Melting point | 244.0 to 248.0 °C |
Properties (reference)
| Melting Point | 246 °C |
| Solubility in water | Insoluble |
| Degree of solubility in water | < 0.1 g/l |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| RTECS# | JM5562500 |
Transport Information:
| HS Number | 2933998090 |
Application
Nevirapine: A Non-Nucleoside Reverse Transcriptase Inhibitor
Nevirapine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that active against HIV-1. Nevirapine selectively inhibits HIV-1 but not HIV-2 and any of the human DNA polymerases. Nucleoside reverse transcriptases (NRTIs) compete with natural nucleic acid triphosphates for inhibitory action, whereas nevirapine does not compete with the triphosphates. Nevirapine bind to an active site of the reverse transcriptase molecule of HIV-1, and inhibits the transcriptase activity. Therefore, nevirapine is also active against NRTI (e.g. azidothymidine) resistant HIV-1. (The product is for research purpose only.)
References
- Crystal structure at 3.5 Å resolution of HIV-1 reverse transcriptase complexed with an inhibitor
- Inhibition of HIV-1 replication by a nonnucleoside reverse transcriptase inhibitor
- Mechanism of inhibition of HIV-1 reverse transcriptase by nonnucleoside inhibitors
- Nevirapine: a review of its development, pharmacological profile and potential for clinical use
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