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Published TCIMAIL newest issue No.198
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CAS RN: 122320-73-4 | Product Number: R0106
Rosiglitazone
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Purity: >98.0%(T)(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 200MG |
19,00 €
|
Contact Us | 7 |
|
| 1G |
58,00 €
|
2 | ≥60 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | R0106 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__8H__1__9N__3O__3S = 357.43 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image), 200MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 122320-73-4 |
| Reaxys Registry Number | 7082202 |
| PubChem Substance ID | 253659589 |
| Merck Index (14) | 8265 |
| MDL Number | MFCD00871760 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 154.0 to 158.0 °C |
Properties (reference)
| Melting Point | 156 °C |
GHS
Related Laws:
| RTECS# | XJ5813850 |
Transport Information:
| HS Number | 2934100090 |
Application
Rosiglitazone: An Agonist at the Peroxisome Proliferator-Activated Receptor of the Gamma Subtype (PPARγ)
Rosiglitazone, a thiazolidinedione, is an agonist at the peroxisome proliferator-activated receptor of the gamma subtype (PPARγ), a transcription-regulating receptor. PPAR receptors are found in peripheral tissues important for insulin action. Activation of PPARγ nuclear receptors modulates the transcription of a number of insulin responsive genes involved in the control of glucose and lipid metabolism. Therefore, rosiglitazone decreases insulin resistance in the periphery tissues and in the liver resulting in increased insulin-dependent glucose disposal and decreased hepatic glucose output. And recently, it has been reported that rosiglitazone is associated with cardiovascular problems. (The product is for research purpose only.)
References
- An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPARγ)
- The anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways
- Evidence for a potent antiinflammatory effect of rosiglitazone
- Structure, endothelial function, cell growth, and inflammation in blood vessels of angiotensin II-infused rats: Role of peroxisome proliferator-activated receptor-γ
- β-Cell mass dynamics in Zucker diabetic fatty rats: rosiglitazone prevents the rise in net cell death
- Rosiglitazone (a review)
- Rosiglitazone revisited: an updated meta-analysis of risk for myocardial infarction and cardiovascular mortality (a review)
- Simultaneous estimation of six anti-diabetic drugs-glibenclamide, gliclazide, glipizide, pioglitazone, repaglinide and rosiglitazone: development of a novel HPLC method for use in the analysis of pharmaceutical formulations and its application to human plasma assay
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