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CAS RN: 133550-30-8 | Product Number: T2962

Tyrphostin AG 490


Purity: >98.0%(T)(HPLC)
Synonyms:
  • (E)-N-Benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide
Documents:
20MG
€35.00
1   ≥20 
100MG
€121.00
1   7  
1G
€638.00
1   5  

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*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).


Product Number T2962
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__1__7H__1__4N__2O__3 = 294.31  
Physical State (20 deg.C) Solid
Storage Temperature <0°C
Store Under Inert Gas Store under inert gas
Condition to Avoid Light Sensitive,Air Sensitive,Heat Sensitive
CAS RN 133550-30-8
Reaxys Registry Number 4323263
PubChem Substance ID 253661829
MDL Number

MFCD00236452

Specifications
Purity(HPLC) min. 98.0 area%
Purity(Neutralization titration) min. 98.0 %
Properties (reference)
Melting Point 215 °C
GHS
Pictogram Pictogram
Signal Word Danger
Hazard Statements H301 : Toxic if swallowed.
H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P270 : Do not eat, drink or smoke when using this product.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ eye protection/ face protection.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
Related Laws: / Compliance with laws, Regulations
RTECS# UC6316197
Transport Information:
UN Number UN3439
Class 6.1
Packing Group III
HS Number 2926907090
Application
JAK Inhibitor
References

1)The Janus kinases (Jaks)

K. Yamaoka, P. Saharinen, M. Pesu, V. E. T. Holt III, O. Silvennoinen, J. J. O’Shea, Genome Biol. 2004, 5, 253.

2)Janus kinases: Components of multiple signaling pathways

S. G. Rane, E. P. Reddy, Oncogene 2000, 19, 5662.

3)Tyrphostines. 2. Heterocyclic and α-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases

A. Gazit, N. Osherov, I. Posner, P. Yaish, E. Poradosu, C. Gilon, A. Levitzki, J. Med. Chem. 1991, 34, 1896.

4)Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor

N. Meydan, T. Grunberger, H. Dadi, M. Shahar, E. Arpaia, Z. Lapidot, J. S. Leeder, M. Freedman, A. Cohen, A. Gazit, A. Levitzki, C. M. Roifman, Nature 1996, 379, 645.

5)JAK3, STAT, and MAPK signaling pathways as novel molecular targets for the tyrphostin AG-490 regulation of IL-2-mediated T cell response

L. H. Wang, R. A. Kirken, R. A. Erwin, C.-R. Yu, W. L. Farrar, J. Immunol. 1999, 162, 3897.

6)Tyrphostin AG-490 inhibits cytokine-mediated JAK3/STAT5a/b of signal transduction and cellular proliferation of antigen-activated human T cells

R. A. Kirken, R. A. Erwin, D. Taub, W. J. Murphy, F. Behbod, L. Wang, F. Pericle, W. L. Farrar, J. Leukoc. Biol. 1999, 65, 891.

7)JAK2 tyrosine kinase inhibitor tyrphostin AG490 downregulates the mitogen-activated protein kinase (MAPK) and signal transducer and activator of transcription (STAT) pathways and induces apoptosis in myeloma cells

J. De Vos, M. Jourdan, K. Tarte, C. Jasmin, B. Klein, Br. J. Haematol. 2000, 109, 823.


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