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Published TCIMAIL newest issue No.198
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CAS RN: 2826-26-8 | Product Number: T3074
Tyrphostin A1
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Purity: >98.0%(GC)
Synonyms:
- Tyrphostin 1
- (4-Methoxybenzylidene)malononitrile
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 200MG |
€70.00
|
1 | 2 |
|
| 1G |
€248.00
|
2 | 3 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | T3074 |
| Purity / Analysis Method | >98.0%(GC) |
| Molecular Formula / Molecular Weight | C__1__1H__8N__2O = 184.20 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 2826-26-8 |
| Reaxys Registry Number | 1869845 |
| PubChem Substance ID | 253662620 |
| MDL Number | MFCD00019787 |
Specifications
| Appearance | Light orange to Yellow to Green powder to crystal |
| Purity(GC) | min. 98.0 % |
| Melting point | 113.0 to 117.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 115 °C |
| Maximum Absorption Wavelength | 350 nm (H__2O) |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. |
Related Laws:
Transport Information:
| UN Number | UN3439 |
| Class | 6.1 |
| Packing Group | III |
| HS Number | 2926907090 |
Application
Kinase Inhibitor
References
- 1)Tyrphostins I: Synthesis and biological activity of rotein tyrosine kinase inhibitors
- 2)Differential requirements for JAK2 and TYK2 in T cell proliferation and IFN-γ production induced by IL-12 alone or together with IL-18
- 3)Constitutive activation of a slowly migrating isoform of Stat3 in mycosis fungoides: Tyrphostin AG490 inhibits Stat3 activation and growth of mycosis fungoides tumor cell lines
- 4)Epidermal growth factor system regulates mucin production in airways
- 5)Enhancement of recombinant adeno-associated virus type 2-mediated transgene expression in a lung epithelial cell line by inhibition of the epidermal growth factor receptor
PubMed Literature
Documents
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