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CAS RN: 147-94-4 | Product Number: C2035

Cytarabine


Purity: >98.0%(T)(HPLC)
Synonyms:
  • 4-Amino-1-β-D-arabinofuranosyl-2(1H)-pyrimidinone
  • Arabinocytidine
  • Cytosine β-D-Arabinofuranoside
  • Ara-C
Documents:
1G
£28.00
1   ≥100 
5G
£89.00
8   ≥40 

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Note:

This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.

Product Number C2035
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__9H__1__3N__3O__5 = 243.22 
Physical State (20 deg.C) Solid
Storage Temperature Room Temperature (Recommended in a cool and dark place, <15°C)
CAS RN 147-94-4
Related CAS RN 69-74-9
Reaxys Registry Number 89175
PubChem Substance ID 87558791
Merck Index (14) 2784
Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %
Specific rotation [a]20/D +155.0 to +162.0 deg(C=1, H2O)
NMR confirm to structure
Properties (reference)
Melting Point 214 °C
Specific Rotation 158° (C=1,H2O)
Maximum Absorption Wavelength 272(H2O) nm
Solubility in water Soluble
GHS
Related Laws:
EC Number 205-705-9
RTECS# HA5425000
Transport Information:
HS Number 2934999090
Application
Cytarabine (ara-C): D-Arabinosyl Nucleoside exhibiting Anti-Leukemia and Anti-DNA Virus Activities

Certain D-arabinosyl nucleosides, notably cytarabine (ara-C) and vidarabine (ara-A) [V0098] are used as an anti-leukemia agent and an anti-DNA virus agent. Ara-C and ara-A are cell cycle phase-specific antineoplastic agents, affecting cells only during the S-phase of cell division. Intracellularly, ara-C and ara-A are converted into the 5-triphosphates (ara-CTP and ara-ATP), which are the active metabolites. The mechanism of actions are not completely understood, but it appear that ara-CTP and ara-ATP act through the inhibition of tumor cell or virus-induced DNA polymerases, competing with dCTP and dATP, respectively. Incorporation of them into DNA and RNA also contribute to their cytotoxicity. (The product is for research purpose only.)

References


PubMed Literature


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