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Published TCIMAIL newest issue No.199
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CAS RN: 69975-86-6 | Product Number: D4302
Doxofylline
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 7-(1,3-Dioxolan-2-ylmethyl)theophylline
- 7-(1,3-Dioxolan-2-ylmethyl)-1,3-dimethyl-1H-purine-2,6-dione
- 7-(1,3-Dioxolan-2-ylmethyl)-1,3-dimethylxanthine
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 1G |
£21.00
|
1 | 12 |
|
|
| 25G |
£235.00
|
1 | 12 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | D4302 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__1H__1__4N__4O__4 = 266.26 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 69975-86-6 |
| Reaxys Registry Number | 561195 |
| PubChem Substance ID | 253659730 |
| Merck Index (14) | 3438 |
| MDL Number | MFCD00865218 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 142.0 to 146.0 °C |
Properties (reference)
| Melting Point | 144 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| EC Number | 274-239-6 |
| RTECS# | XH5135000 |
Transport Information:
| HS Number | 2933599590 |
Application
Studies of the Mechanism of Action of Doxofylline
References
- Doxofylline: a new generation xanthine bronchodilator devoid of major cardiovascular adverse effects
- The mechanism of action of doxofylline is unrelated to HDAC inhibition, PDE inhibition or adenosine receptor antagonism
Application
Analyses of Doxofylline in Serum
References
- Non-extraction HPLC method for simultaneous measurement of dyphylline and doxofylline in serum
- F. Tagliaro, R. Dorizzi, A. Frigerio, M. Marigo, Clin. Chem. 1990, 36, 113.
- Development and validation of a stability-indicating RP-HPLC method for analysis of doxofylline in human serum. Application of the method to a pharmacokinetic study
- R. Gannu, S. Bandari, S. G. Sudke, Y. M. Rao, B. P. Shankar, Acta Chromatogr. 2007, 19, 149.
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