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Published TCIMAIL newest issue No.198
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CAS RN: 36791-04-5 | Product Number: R0077
Ribavirin
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Purity: >98.0%(HPLC)(N)
Synonyms:
- 1-(β-D-Ribofuranosyl)-1,2,4-triazole-3-carboxamide
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 100MG |
19,00 €
|
Contact Us | ≥60 |
|
| 500MG |
68,00 €
|
2 | ≥40 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
Supplemental Product Information:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| Product Number | R0077 |
Purity / Analysis Method 
|
>98.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | C__8H__1__2N__4O__5 = 244.21 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 36791-04-5 |
| Reaxys Registry Number | 892462 |
| PubChem Substance ID | 87559671 |
| Merck Index (14) | 8198 |
| MDL Number | MFCD00058564 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Specific rotation [a]20/D | -33.0 to -37.0 deg(C=1, H2O) |
Properties (reference)
| Specific Rotation | -36° (C=1,H2O) |
| Solubility in water | Soluble |
| Degree of solubility in water | 142 g/l 25 °C |
| Solubility (slightly sol. in) | Alcohol |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H360 : May damage fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
Related Laws:
| RTECS# | XZ4250000 |
Transport Information:
| HS Number | 2934999090 |
Application
Ribavirin: A Ribonucleoside Analog with Antiviral Activity
Ribavirin, a ribonucleoside analog, shows antiviral activity against a variety of viruses both in vitro and in vivo. Although its mechanism of action remains unknown exactly, five distinct mechanisms have been proposed to explain the antiviral properties of ribavirin. These include both direct mechanisms (interference with RNA capping, RNA polymerase inhibition, lethal mutagenesis) and indirect mechanisms (inosine monophosphate dehydrogenase inhibition, immunomodulatory effects). Ribavirin is widely used in combination with interferon-α (IFN-α) to treat hepatitis C virus infection. The addition of ribavirin greatly improves IFN-α responses. (The product is for research purpose only.)
References
- The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen
- RNA virus error catastrophe: direct molecular test by using ribavirin
- Mechanism of action of ribavirin in the combination treatment of chronic HCV infection (a review)
- Mechanism of action of interferon and ribavirin in treatment of hepatitis C (a review)
- Mechanisms of action of ribavirin against distinct viruses
- The metabolism, pharmacokinetics and mechanisms of antiviral activity of Ribavirin against hepatitis C virus (a review)
PubMed Literature
Documents
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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