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CAS RN: 144060-53-7 | Product Number: F0847
Febuxostat
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Purity: >97.0%(T)(HPLC)
Synonyms:
- 2-(3-Cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic Acid
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 1G |
€16.00
|
2 | ≥60 |
|
|
| 5G |
€47.00
|
2 | 11 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | F0847 |
Purity / Analysis Method 
|
>97.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__6H__1__6N__2O__3S = 316.38 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 144060-53-7 |
| Reaxys Registry Number | 8005333 |
| PubChem Substance ID | 172089002 |
| Merck Index (14) | 3948 |
| MDL Number | MFCD00871598 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(Neutralization titration) | min. 97.0 % |
| Melting point | 207.0 to 211.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 209 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 + H312 + H332 : Harmful if swallowed, in contact with skin or if inhaled. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P261 : Avoid breathing dust. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water. Call a POISON CENTER/doctor if you feel unwell. P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. |
Related Laws:
| RTECS# | XJ3675310 |
Transport Information:
| HS Number | 2934100090 |
Application
Studies on the Inhibition of Xanthine Oxidoreductase, Febuxostat
References
- An Extremely Potent Inhibitor of Xanthine Oxidoreductase
- Selectivity of febuxostat, a novel non-purine inhibitor of xanthine oxidase/xanthine dehydrogenase
- Hypouricemic effect of the novel xanthine oxidase inhibitor, TEI-6720, in rodents
- Effects of febuxostat on metabolic and renal alterations in rats with fructose-induced metabolic syndrome
Application
Febuxostat: A Non-Purine Selective Xanthine Oxidase (XO) Inhibitor
Febuxostat (TEI-6720) is a non-purine selective xanthine oxidase (XO) inhibitor. Uric acid [U0018] is the end product of purine metabolism in humans and is generated in the cascade of hypoxanthine [H0311] → xanthine [X0004] → uric acid. The both transformations are catalyzed by XO. Febuxostat is a XO inhibitor that significantly reduces uric acid levels in blood and urine. Therefore, in clinical, febuxostat is used for the treatment of hyperuricemia and gout. For your reference, [E1049] [E1394] and [E1414] are synthetic intermediates of febuxostat. (The product is for research purpose only.)
References
- An extremely potent inhibitor of xanthine oxidoreductase. Crystal structure of the enzyme-inhibitor complex and mechanism of inhibition
- Selectivity of febuxostat, a novel non-purine inhibitor of xanthine oxidase/xanthine dehydrogenase
- Febuxostat: a selective xanthine oxidase inhibitor for the treatment of hyperuricemia and gout (a review)
- Quantification of uric acid, xanthine and hypoxanthine in human serum by HPLC for pharmacodynamic studies
- Development and Validation of a Stability-Indicating RP-HPLC Method for the Determination of Febuxostat (a Xanthine Oxidase Inhibitor)
PubMed Literature
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