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CAS RN: 26386-88-9 | Product Number: D1672

Diphenylphosphoryl Azide

Purity: >97.0%(GC)
  • DPPA
Contact Us ≥20 
7   ≥20 
1   ≥20 

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Product Number D1672
Purity / Analysis Method >97.0%(GC)
Molecular Formula / Molecular Weight C__1__2H__1__0N__3O__3P = 275.20  
Physical State (20 deg.C) Liquid
Storage Temperature 0-10°C
Store Under Inert Gas Store under inert gas
Condition to Avoid Moisture Sensitive,Heat Sensitive
CAS RN 26386-88-9
Reaxys Registry Number 2058967
PubChem Substance ID 87568148
MDL Number


Appearance Colorless to Almost colorless clear liquid
Purity(GC) min. 97.0 %
Properties (reference)
Specific Gravity (20/20) 1.28
Refractive Index 1.55
Solubility in water Decomposes in contact with water,Insoluble
Solubility (very soluble in) Toluene,Acetone,Dimethylformamide
Pictogram Pictogram
Signal Word Danger
Hazard Statements H300 + H310 + H330 : Fatal if swallowed, in contact with skin or if inhaled.
H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
Precautionary Statements P260 : Do not breathe dust/ fume/ gas/ mist/ vapours/ spray.
P262 : Do not get in eyes, on skin, or on clothing.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
P302 + P352 + P310 : IF ON SKIN: Wash with plenty of water. Immediately call a POISON CENTER/doctor.
P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor.
P403 + P233 : Store in a well-ventilated place. Keep container tightly closed.
Related Laws:
EC Number 247-644-0
Transport Information:
UN Number UN3278
Class 6.1
Packing Group II
HS Number 2929900090
Phosphoryl Azide for Nosylation via Azidation


Phosphoryl Azide for Azidations


Condensing Agent

Experimental procedure2): To an ice-cooled mixture containing 1 (2.5 mmol) and 2 (2.5 mmol) in dry DMF (15 mL), DPPA (3.0 mmol) is slowly added, followed by drop-wise addition of Et3N (6.3 mmol). The reaction mixture is kept at 0 °C for another 2 h, and then allowed to warm up to room temperature. After 24 h, the reaction mixture is diluted with EtOAc (80 mL) and washed with an aqueous solution of citric acid (10%, 50 mL), H2O (50 mL), saturated aqueous NaHCO3 (50 mL), H2O (50 mL), and brine (50 mL). The organic phase is dried over Na2SO4, filtered and evaporated under reduced pressure. The resulting residue is purified by column chromatography to afford 3 (83% yield).


DPPA: A Stable and Easy-to-handle Azidating Agent

Experimental procedure2): Diphenylphosphoryl azide (0.87 mL, 4.04 mmol) is added to a solution of alcohol 1 (98 mg, 0.40 mmol), PPh3 (211 mg, 0.81 mmol) and DEAD (0.37 mL, 40% in toluene, 0.81 mmol) in THF (5 mL) and the reaction is stirred at room temperature for 24 h. Concentration in vacuo and purification by column chromatography (Et2O:hexanes = 1:9) gave 2 (108 mg, 0.40 mmol, 99%) as a colorless oil.


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