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CAS RN: 60239-18-1 | Product Number: T1875
1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic Acid
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Purity: >97.0%(T)
Synonyms:
- DOTA
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 200MG |
$164.00
|
4 | ≥40 | Contact Us | |
| 1G |
$567.00
|
2 | ≥40 | Contact Us |
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to order our products. The above prices do not include freight cost, customs, and other charges to the destination.
* The storage conditions are subject to change without notice.
| Product Number | T1875 |
Purity / Analysis Method 
|
>97.0%(T) |
| Molecular Formula / Molecular Weight | C__1__6H__2__8N__4O__8 = 404.42 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image), 200MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 60239-18-1 |
| Reaxys Registry Number | 1186987 |
| PubChem Substance ID | 87560717 |
| MDL Number | MFCD00068657 |
Specifications
| Appearance | White to Almost white powder to crystaline |
| Purity(Chelometric Titration) | min. 97.0 % |
Properties (reference)
| Melting Point | 267 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
Transport Information:
| H.S.code* | 2933.99-000 |
Application
The Reviews of DOTA: One of the Preeminent Carriers of Metal-Based Imaging Contrast Agents for Biomedical Imaging.
1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) is one of the preeminent carriers of metal-based imaging contrast agents. Metal complexes of DOTA-peptide or others conjugates have increasingly used in Magnetic Resonance Imaging (MRI), Positron Emission Tomography (PET), Single Photon Emission Computed Tomography (SPECT) and Fluorescence imaging.
References
- The Synthesis and Chelation Chemistry of DOTA-Peptide Conjugates
- PET (positron emission tomography) imaging of biomolecules using metal-DOTA complexes: a new collaborative challenge by chemists, biologists, and physicians for future diagnostics and exploration of in vivo dynamics
- 64Cu-labeled tetrameric and octameric RGD peptides for small-animal PET of tumor αvβ3 integrin expression
- The coordination chemistry of 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid (H4DOTA): Structural overview and analyses on structure-stability relationships
- The ubiquitous DOTA and its derivatives: the impact of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid on biomedical imaging
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