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Published TCIMAIL newest issue No.198
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CAS RN: 198470-84-7 | Product Number: P2579
Parecoxib
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Purity: >97.0%(T)(HPLC)
Synonyms:
- N-[[4-(5-Methyl-3-phenylisoxazol-4-yl)phenyl]sulfonyl]propionamide
Product Documents:
| Size | Unit Price | Belgium | Japan* |
|---|---|---|---|
| 50MG |
92,00 €
|
Contact Us | 20 |
| 250MG |
317,00 €
|
Contact Us | 19 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | P2579 |
Purity / Analysis Method 
|
>97.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__9H__1__8N__2O__4S = 370.42 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 198470-84-7 |
| Reaxys Registry Number | 8640266 |
| Merck Index (14) | 7036 |
| MDL Number | MFCD08141856 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(Neutralization titration) | min. 97.0 % |
| Melting point | 153.0 to 157.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 155 °C |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H360 : May damage fertility or the unborn child. H373 : May cause damage to organs through prolonged or repeated exposure. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. |
Related Laws:
| RTECS# | TX1478700 |
Transport Information:
| HS Number | 2935909099 |
Application
Parecoxib: A Selective Cyclooxygenase-2 (COX-2) Inhibitor
Parecoxib, a prodrug of valdecoxib [V0133], is a selective inhibitor of cyclooxygenase-2 (COX-2) which is an inducible isoform of COX. The mechanism of action is mainly by inhibition of the enzyme COX in the arachidonic acid metabolism pathway, resulting in reduced prostaglandin synthesis. In theory, a drug that selectively inhibited COX-2 might block inflammation, pain, and fever produced by prostaglandins while reducing the side effects (gastric erosions and ulcers) associated with inhibition of COX-1. The sodium salt is widely used for clinical. (The product is for research purpose only.)
References
- Parecoxib (parecoxib sodium)
- The second generation of COX-2 inhibitors: what advantages do the newest offer? (a review)
- Selective cyclooxygenase-2 inhibitors: similarities and differences
- Simultaneous detection and quantification of parecoxib and valdecoxib in canine plasma by HPLC with spectrofluorimetric detection: development and validation of a new methodology.
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