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CAS RN: 320-67-2 | Product Number: A2033
5-Azacytidine
Purity: >98.0%(T)
Synonyms:
- 4-Amino-1-(β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one
- Ladakamycin
Product Documents:
Size | Unit Price | Belgium | Japan* | Quantity |
---|---|---|---|---|
100MG |
19,00 €
|
2 | 11 |
|
1G |
122,00 €
|
1 | ≥40 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
Product Number | A2033 |
Purity / Analysis Method | >98.0%(T) |
Molecular Formula / Molecular Weight | C__8H__1__2N__4O__5 = 244.21 |
Physical State (20 deg.C) | Solid |
Storage Temperature | Frozen (<0°C) |
Condition to Avoid | Light Sensitive,Heat Sensitive |
CAS RN | 320-67-2 |
Reaxys Registry Number | 620461 |
PubChem Substance ID | 87559665 |
Merck Index (14) | 887 |
MDL Number | MFCD00006539 |
Specifications
Appearance | White to Almost white powder to crystal |
Purity(HPLC) | min. 97.0 area% |
Purity(Nonaqueous Titration) | min. 98.0 % |
Properties (reference)
Melting Point | 216 °C(dec.) |
Solubility in water | Soluble |
GHS
Pictogram | |
Signal Word | Danger |
Hazard Statements | H302 : Harmful if swallowed. H340 : May cause genetic defects. H350 : May cause cancer. |
Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. |
Related Laws:
EC Number | 206-280-2 |
RTECS# | XZ3017500 |
Transport Information:
HS Number | 2934999090 |
Application
An Inhibitor of DNA Methylation
The cytidine analogs 5-azacytidine and 5-aza-2'-deoxycytidine [A2232] are inhibitors of DNA methyltransferases (DNMTs) which catalyze the transfer of a methyl group to DNA. DNA methylation is an epigenetic factor and plays an important role in regulating gene expression. 5-Azacytidine and 5-aza-2'-deoxycytidine are the currently most advanced agents for epigenetic cancer therapies. (The product is for research purpose only.)
References
- Cellular differentiation, cytidine analogs and DNA methylation
- 5-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy (a review)
- The Role of Methylation in Gene Expression (a review)
- Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine
- Quantification of 5-azacytidine in plasma by electrospray tandem mass spectrometry coupled with high-performance liquid chromatography
Application
Aminophylline: A Water Soluble Theophylline
References
- Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds
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