Cyanine dyes, including Cyanine3, Cyanine5, Cyanine5.5, Cyanine 7 and Indocyanine Green (ICG) (Product No. I0535) are important compounds in biological applications. Among them, ICG, which is a heptamethine cyanine dye, has an absorption wavelength and an emission wavelength in the near-infrared window (about 800 nm), and is used for ophthalmic angiography and examining cardiac output, hepatic function, gaster/liver bloodstream. But ICG is nonspecific and cannot stain a certain tissue. Alternatively, researchers have been trying to utilize conjugates of heptamethine cyanine dye, which has functional group, with proteins including antibodies for diagnosis of a specific disease, drug release in a specific tissue, or fluorescence-guided surgery.1-6) In particular, NIR fluorophore-mAb conjugates, which are complexes with monoclonal antibodies (mAbs), are useful as contrast agents for tumor targeting. As a near-infrared dye that can be conjugated with such antibodies, we introduce a cyanine dye that was added a carboxyl group into the polymethine structure of ICG.7,8) ICG Carboxylic Acid (Product No. O0574) can be expected to be used as a material with characteristics that are close to but different from ICG, such as solubility and specific reactivity with biomolecules. For example, a probe for cellular hypoxia imaging that can "turn on" fluorescence with nitroreductase has been reported.9)
We offer ICG Carboxylic Acid at a lower price than ICG. We have 1 g and 5 g packages, and will be happy to discuss bulk synthesis requests.
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