text.skipToContent text.skipToNavigation

Maximum quantity allowed is 999

Please select the quantity

CAS RN: 54-62-6 | Product Number: A0410


Purity: >97.0%(T)(HPLC)
  • 4-Aminofolic Acid
  • 4-Amino-PGA
  • 4-Aminopteroyl-L-glutamic Acid

Contact Us

Contact Us

Contact Us

7   8  

Contact Us

* Please check with "Check Estimated Ship Date" for details. The shipping date may vary depending on the quantity.
* For the case that without specific estimated shipping data, e.g.: If displayed as "will be shipped after 8 working days", the products will be shipped 8 working days later after ordering.
* Available Stock: Prompt shipment (for products) in Saitama/Hyogo warehouse. Stock in other WH: 2-3 Business Days
* Please contact us if you need further information.
* To send your quote request for bulk quantities, please click on the "Request Bulk Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.


Previously this product had been labeled as a hydrate form both in product name and molecular formula. The hydrate form had no exclusive CAS RN and used to share the same CAS RN as the anhydrous form.
To avoid any misleading information and since moisture in product is considered as an impurity, we have decided to remove the term 'Hydrate' from product name and 'xH2O' from the molecular formula for such products.
Please use it at ease since there is no difference in product quality, even if you see the previous indications on a part of label.

Product Number A0410
Purity / Analysis Method >97.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__1__9H__2__0N__8O__5 = 440.42 
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Store Under Inert Gas Store under inert gas
Condition to Avoid Air Sensitive,Heat Sensitive
Packaging and Container 100MG-Glass Bottle with Plastic Insert (View image),  25MG-Glass Bottle with Plastic Insert (View image)
CAS RN 54-62-6
Reaxys Registry Number 69045
PubChem Substance ID 125308158
Merck Index (14) 472
MDL Number


Appearance White to Amber powder to crystal
Purity(HPLC) min. 97.0 area%
Purity(Neutralization titration) min. 97.0 %(calcd.on anh.substance)
Specific rotation [a]20/D +18.0 to +22.0 deg(C=1、0.1mol/LNaOH sol.)(calcd.on anh.substance)
Water 3.0 to 10.0 %
NMR confirm to structure
Properties (reference)
Melting Point 222 °C(dec.)
Specific Rotation 20° (C=1,0.1mol/L NaOH)
Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H300 : Fatal if swallowed.
H360 : May damage fertility or the unborn child.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P270 : Do not eat, drink or smoke when using this product.
P202 : Do not handle until all safety precautions have been read and understood.
P201 : Obtain special instructions before use.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
P405 : Store locked up.
Related Laws:
RTECS# MA1050000
Transport Information:
UN Number UN2811
Class 6.1
Packing Group I
Aminopterin: A Dihydrofolic Acid Reductase (DHFR) Inhibitor

Aminopterin, an amino derivative of folic acid [F0043], is a dihydrofolic acid reductase (DHFR) inhibitor. DHFR is an enzyme that reduces dihydrofolic acid to tetrahydrofolic acid, using nicotinamide adenine dinucleotide phosphate (NADPH) as electron donor, and a key enzyme in the synthesis of thymidylate and DNA. The inhibition causes the depletion of nucleotide precursors and inhibition of DNA. Aminopterin used to use as an antineoplastic agent in the treatment of leukemia. In the 1950’s, a less potent but less toxic methotrexate [M1664] began to replace in clinical use. (The product is for research purpose only.)


PubMed Literature

Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
Please select Language.

The requested SDS is not available.

Please Contact Us for more information.

C of A & Other Certificates
Please enter Lot Number Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
Analytical Charts
Please enter Lot Number Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.

The requested analytical chart is not available. Sorry for the inconvenience.

Other Documents

Session Status
Your session will timeout in 10 minutes. You will be redirected to the HOME page after session timeout. Please click the button to continue session from the same page. minute. You will be redirected to the HOME page after session timeout. Please click the button to continue session from the same page.

Your session has timed out. You will be redirected to the HOME page.