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CAS RN: 1937-19-5 | Product Number: A1129

Aminoguanidine Hydrochloride


Purity: >98.0%(T)
Synonyms:
Documents:
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Product Number A1129
Purity / Analysis Method >98.0%(T)
Molecular Formula / Molecular Weight CH__6N__4·HCl = 110.55 
Physical State (20 deg.C) Solid
Store Under Inert Gas Store under inert gas
Condition to Avoid Hygroscopic
CAS RN 1937-19-5
Related CAS RN 79-17-4
Reaxys Registry Number 3909606
PubChem Substance ID 87562613
MDL Number

MFCD00039074

Specifications
Appearance White to Almost white powder to crystal
Purity( Potassium iodate Method) min. 98.0 %
Melting point 161.0 to 167.0 °C
Properties (reference)
Melting Point 165 °C
Solubility in water Completely soluble
Solubility (soluble in) Alcohol
Solubility (insoluble in) Ether
GHS
Pictogram Pictogram
Signal Word Warning
Hazard Statements H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
Precautionary Statements P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ eye protection/ face protection.
P302 + P352 : IF ON SKIN: Wash with plenty of water.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P362 + P364 : Take off contaminated clothing and wash it before reuse.
P332 + P313 : If skin irritation occurs: Get medical advice/ attention.
Related Laws:
RTECS# ME8430000
Transport Information:
Application
Two Biological Effects of Aminoguanidine Hydrochloride

It is reported that aminoguanidine hydrochloride has two important biological effects. Firstly, it is effective for the prevention of formation of advanced glycation endproducts (AGEs) associated with pathogenesis of secondary complications to diabetes and with cardiovascular changes in aging.1-3) Aminoguanidine hydrochloride reacts rapidly with in vivo glycation α,β-dicarbonyl products such as methylglyoxal, glyoxal [G0152], and 3-deoxyglucosone to prevent the formation of AGEs.
Secondly, it inhibits of the individual isoforms of nitric oxide synthase (iNOS) which is one of three key enzymes generating nitric oxide (NO) from L-arginine [ A0526]. iNOS-derived nitric oxide plays an important role in numerous physiological (e.g. blood pressure regulation) and pathophysiological (e.g. inflammation) conditions. 3-6) (The product is for research purpose only.)

References


PubMed Literature


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