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CAS RN: 6398-98-7 | Product Number: A3133
Amodiaquine Dihydrochloride Dihydrate
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 4-[(7-Chloroquinolin-4-yl)amino]-2-[(diethylamino)methyl]phenol Dihydrochloride Dihydrate
Product Documents:
| Size | Unit Price | Saitama (Kawaguchi) | Hyogo (Amagasaki) | Stock in other WH |
Shipping Information
|
|---|---|---|---|---|---|
| 5G |
¥3,400
|
6 | It can be shipped from Saitama warehouse on the same day* | Contact Us | |
| 25G |
¥11,600
|
30 | It can be shipped from Saitama warehouse on the same day* | Contact Us |
* Available Stock: Prompt shipment (for products) in Saitama/Hyogo warehouse. Stock In Other WH: Shipment in about 2-3 Business Days from Saitama warehouse. Please contact us
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
* The displayed price is the unit price and does not include consumption tax. The unit prices displayed are the latest and are subject to change without notice.
* To send your quote request for bulk quantities, please click on the "Request Bulk Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | A3133 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__0H__2__2ClN__3O·2HCl·2H__2O = 464.81 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 6398-98-7 |
| Related CAS RN
|
86-42-0&69-44-3 |
| Reaxys Registry Number | 17163077 |
| PubChem Substance ID | 354335166 |
| Merck Index (14) | 572 |
| MDL Number | MFCD00078857 |
Specifications
| Appearance | White to Yellow to Orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Water | 7.0 to 9.0 % |
| NMR | confirm to structure |
Properties (reference)
| Maximum Absorption Wavelength | 342 nm (MeOH) |
| Solubility in water | Soluble |
| Solubility (soluble in) | Methanol |
| Solubility (insoluble in) | Alcohol |
GHS
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Application
Amodiaquine Dihydrochloride: A 4-Aminoquinoline Antimalarial Agent
Amodiaquine dihydrochloride is a synthetic 4-aminoquinoline antimalarial agent. Amodiaquine is mainly metabolized hepatically towards its major active metabolite N-desethylamodiaquine, by the cytochrome P450 2C8 (CYP2C8). The mechanism of action of amodiaquine against plasmodium is not yet completely understood, but the most plausible explanation is that the active metabolite penetrate the infected red blood cells and prevent the parasite from polymerizing heme into a malarial metabolite called hemozoin, leading to parasite death. Recently, the antimalarial combination of amodiaquine plus artesunate [A2191] has been extensively studied and good efficacy and tolerability has been reported. (The product is for research purpose only.)
References
- Amodiaquine clearance and its metabolism to N-desethylamodiaquine is mediated by CYP2C8: a new high affinity and turnover enzyme-specific probe substrate (a review)
- CYP2C8 and antimalaria drug efficacy (a review)
- Artemisinin-based combination treatment of falciparum malaria
- Amodiaquine hydrochloride (a review on the synthesis, properties, analysis and pharmacology)
- High-performance liquid chromatographic method for determination of amodiaquine, chloroquine and their monodesethyl metabolites in biological samples
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