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CAS RN: 90357-06-5 | Product Number: B3206
Bicalutamide
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Purity: >98.0%(HPLC)(N)
Deleterious substance
Synonyms:
- N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropionamide
Documents:
| Size | Unit Price | Saitama (Kawaguchi) | Hyogo (Amagasaki) | Stock in other WH |
More Stock Info
|
|---|---|---|---|---|---|
| 200MG |
¥5,900
|
≥40 | 1 | 6 | |
| 1G |
¥20,500
|
5 | 1 | ≥40 |
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* To send your quote request for bulk quantities, please click on the "Request Bulk Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
* For the case that without specific estimated shipping data, e.g.: If displayed as "will be shipped after 8 working days", the products will be shipped 8 working days later after ordering.
* Available Stock: Prompt shipment (for products) in Saitama/Hyogo warehouse. Stock in other WH: 2-3 Business Days
* Please contact us if you need further information.
* To send your quote request for bulk quantities, please click on the "Request Bulk Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Melting point | 194.0 to 198.0 °C |
Properties (reference)
| Melting Point | 196 °C |
| Maximum Absorption Wavelength | 270(CH3CN) nm |
GHS
| Pictogram |
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| Signal Word | Danger |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. H360 : May damage fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P405 : Store locked up. |
Related Laws:
| Poisonous or Deleterious | Deleterious substance |
| RTECS# | TX1413500 |
Transport Information:
Application
Bicalutamide: A Non-Steroidal Androgen Receptor Antagonist
Bicalutamide (ICI 176334) and flutamide [F0663] are non-steroidal androgen receptor antagonists with antiandrogenic activity. Testosterone [T0027], the most important androgen, converted to 5α-dihydrotestosterone (DHT) [A0462] by 5α-reductase type 2 which reduces the 4,5-double bond of testosterone in prostate cells. DHT has two or three times greater androgen receptor (AR) affinity than testosterone. Upon DHT binding, the AR undergoes a conformational change and releases heat shock proteins (HSPs), resulting in mRNA expression and prostate cell proliferation. Bicalutamide acts as a potent and highly selective competitive antagonist of the AR, blocks the conversion of testosterone to DHT, and inhibits the proliferation of prostate cells. Bicalutamide and flutamide are used for the treatment of prostate cancer and other androgen-dependent conditions. For your reference, [C3607] is a synthetic intermediate of bicalutamide. (The product is for research purpose only.)
References
- ICI 176,334: a novel non-steroidal, peripherally selective antiandrogen
- Novel Mutations of Androgen Receptor: A Possible Mechanism of Bicalutamide Withdrawal Syndrome
- Switch from antagonist to agonist of the androgen receptor blocker bicalutamide is associated with prostate tumour progression in a new model system
- The androgen receptor in LNCaP cells contains a mutation in the ligand binding domain which affects steroid binding characteristics and response to antiandrogens
- Bicalutamide functions as an androgen receptor antagonist by assembly of a transcriptionally inactive receptor
- Isolation and characterization of process related impurities and degradation products of bicalutamide and development of RP-HPLC method for impurity profile study
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