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CAS RN: 10294-34-5 | Product Number: B3556

Boron Trichloride (ca. 9% in Dichloromethane, ca. 1.0mol/L)


Purity:
Poisonous substance |Chemical Substance Law (ENCS):   1-42
Synonyms:
Documents:
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Product Number B3556
Molecular Formula / Molecular Weight BCl__3 = 117.16 
Physical State (20 deg.C) Liquid
Storage Temperature 0-10°C
Store Under Inert Gas Store under inert gas
Condition to Avoid Air Sensitive,Moisture Sensitive,Heat Sensitive
CAS RN 10294-34-5
Reaxys Registry Number 3903057
PubChem Substance ID 125307282
Merck Index (14) 1348
Specifications
Appearance Colorless to Light yellow to Light orange clear liquid
Concentration(Neutralization titration) 8.0 to 10.0 w/w%
Properties (reference)
GHS
Pictogram Pictogram Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H301 + H331 : Toxic if swallowed or if inhaled.
H314 : Causes severe skin burns and eye damage.
H360 : May damage fertility or the unborn child.
H370 : Causes damage to organs.
H372 : Causes damage to organs through prolonged or repeated exposure.
H373 : May cause damage to organs through prolonged or repeated exposure.
H341 : Suspected of causing genetic defects.
H350 : May cause cancer.
H411 : Toxic to aquatic life with long lasting effects.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P273 : Avoid release to the environment.
P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray.
P270 : Do not eat, drink or smoke when using this product.
P202 : Do not handle until all safety precautions have been read and understood.
P201 : Obtain special instructions before use.
P271 : Use only outdoors or in a well-ventilated area.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P391 : Collect spillage.
P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor.
P303 + P361 + P353 : IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower.
P301 + P330 + P331 : IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P363 : Wash contaminated clothing before reuse.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor.
P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor.
P403 + P233 : Store in a well-ventilated place. Keep container tightly closed.
P405 : Store locked up.
Related Laws:
Chemical Substance Law (ENCS) 1-42
ISHL Group 2 Substance
Mutagens
PRTR Law (New Specific Chemical) Class 1 Designated Chemical Substances
Poisonous or Deleterious Poisonous substance
Transport Information:
UN Number UN2922
Class 8 / 6.1
Packing Group II
Application
Deprotection of Bn Groups using Boron Trichloride

B3556,B3967,B3968,B4415

Reference

  • Protection for the Hydroxyl Group, Including 1,2- and 1,3-Diols
    • P. G. M. Wuts, in Greene’s Protective Groups in Organic Synthesis, 5th ed., ed. by P. G. M. Wuts, John Wiley & Sons, Inc., Hoboken, New Jersey, 2014, Chap. 2, 17.


Application
ortho-Acylation of Anilines using BCl3 (Sugasawa Reaction)

Typical Procedure: 2-Chloroaniline (12.76 g, 100 mmol) and chloroacetonitrile (8.88 g, 250 mmol) are added sequentially to a mixture of AlCl3 pellets (16.0 g, 120 mmol) and BCl3 solution (1.0 M in dichloromethane, 120 mL, 120 mmol) with extra 60 mL dichloromethane cooled in ice bath. The cloudy solution is stirred for 0.5 hour at room temperature before being heated at reflux for 14 hours. The reaction mixture is then cooled in ice bath, quenched with 2N HCl (150 mL), heated at reflux for 20 minutes, cooled, and extracted with dichloromethane (2 x 100 mL). The combined organic layers are dried over MgSO4, concentrated, and chromatographed to give 1-(2-amino-3-chlorophenyl)-2-chloroethanone (13.05 g, 64%).

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