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CAS RN: 327036-89-5 | Product Number: B4436
4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione
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Purity: >98.0%(HPLC)
Synonyms:
- TDZD-8
Documents:
| Size | Unit Price | Saitama (Kawaguchi) | Hyogo (Amagasaki) | Stock in other WH |
|---|---|---|---|---|
| 5MG |
¥7,300
|
24 | 15 | Contact Us |
| 25MG |
¥21,800
|
24 | 14 | Contact Us |
Available Stock: Prompt shipment (for products) in Saitama/Hyogo warehouse. Stock in other WH: 2-3 Business Days
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
* Please contact us if you need further information.
* To send your quote request for bulk quantities, please click on the "Request Bulk Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | B4436 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__0H__1__0N__2O__2S = 222.26 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | -20°C |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Light Sensitive,Air Sensitive,Heat Sensitive |
| CAS RN | 327036-89-5 |
| Reaxys Registry Number | 8763878 |
| PubChem Substance ID | 354334062 |
| MDL Number | MFCD04973552 |
Specifications
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 12.00 to 13.00 % |
| Melting point | 61.0 to 65.0 °C |
Properties (reference)
| Melting Point | 63 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H317 : May cause an allergic skin reaction. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P272 : Contaminated work clothing should not be allowed out of the workplace. P280 : Wear protective gloves. P302 + P352 : IF ON SKIN: Wash with plenty of water. P362 + P364 : Take off contaminated clothing and wash it before reuse. P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention. |
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Application
TDZD-8: An ATP Noncompetitive GSK-3β Inhibitor
Thiadiazolidinone-8 (TDZD-8) is an ATP noncompetitive glycogen synthase kinase 3β (GSK-3β) inhibitor (IC50=2 µM). TDZD-8 is selective against GSK-3β, and has minimal inhibitory effect observed on cyclin-dependent kinase 1 (CDK1), casein kinase II, protein kinase A (PKA). However, it is also reported that TDZD-8 can inhibit the protein kinase C (PKC). Besides, it is reported that TDZD-8 has anti-leukemia activity in leukemia cells, and effects against Alzheimer's disease. (The product is for research purpose only.)
References
- On the Role of Phosphatidylinositol 3-Kinase, Protein Kinase B/Akt, and Glycogen Synthase Kinase-3β in Photodynamic Injury of Crayfish Neurons and Glial Cells
- First Non-ATP Competitive Glycogen Synthase Kinase 3β (GSK-3β) Inhibitors: Thiadiazolidinones (TDZD) as Potential Drugs for the Treatment of Alzheimer's Disease
- Rapid and selective death of leukemia stem and progenitor cells induced by the compound 4-benzyl, 2-methyl, 1,2,4-thiadiazolidine, 3,5 dione (TDZD-8)
- SAR and 3D-QSAR Studies on Thiadiazolidinone Derivatives: Exploration of Structural Requirements for Glycogen Synthase Kinase 3 Inhibitors
Application
Glycogen Synthase Kinase (GSK) Inhibitor
References
- 1)Glycogen synthase kinase-3 from rabbit skeletal muscle, separation from cyclic-AMP-dependent protein kinase and phosphorylase kinase
- 2)Molecular cloning and expression of glycogen synthase kinase-3/Factor A
- 3)GSK-3: Tricks of the trade for a multi-tasking kinase
- 4)Glycogen synthase kinase-3 (GSK-3)-targeted therapy and imaging
- 5)First non-ATP competitive glycogen synthase kinase 3β (GSK-3β) inhibitors: Thiadiazolidinones (TDZD) as potential drugs for the treatment of Alzheimer’s disease
- 6)Rapid and selective death of leukemia stem and progenitor cells induced by the compound 4-benzyl, 2-methyl, 1,2,4-thiadiazolidine, 3,5 dione (TDZD-8)
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