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CAS RN: 327036-89-5 | Product Number: B4436


Purity: >98.0%(HPLC)
  • TDZD-8
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Product Number B4436
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__1__0H__1__0N__2O__2S = 222.26 
Physical State (20 deg.C) Solid
Storage Temperature -20°C
Store Under Inert Gas Store under inert gas
Condition to Avoid Light Sensitive,Air Sensitive,Heat Sensitive
CAS RN 327036-89-5
Reaxys Registry Number 8763878
PubChem Substance ID 354334062
MDL Number


Purity(HPLC) min. 98.0 area%
Elemental analysis(Nitrogen) 12.00 to 13.00 %
Melting point 61.0 to 65.0 °C
Properties (reference)
Melting Point 63 °C
Pictogram Pictogram
Signal Word Warning
Hazard Statements H317 : May cause an allergic skin reaction.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray.
P272 : Contaminated work clothing should not be allowed out of the workplace.
P280 : Wear protective gloves.
P302 + P352 : IF ON SKIN: Wash with plenty of water.
P362 + P364 : Take off contaminated clothing and wash it before reuse.
P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention.
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Transport Information:
TDZD-8: An ATP Noncompetitive GSK-3β Inhibitor

Thiadiazolidinone-8 (TDZD-8) is an ATP noncompetitive glycogen synthase kinase 3β (GSK-3β) inhibitor (IC50=2 µM). TDZD-8 is selective against GSK-3β, and has minimal inhibitory effect observed on cyclin-dependent kinase 1 (CDK1), casein kinase II, protein kinase A (PKA). However, it is also reported that TDZD-8 can inhibit the protein kinase C (PKC). Besides, it is reported that TDZD-8 has anti-leukemia activity in leukemia cells, and effects against Alzheimer's disease. (The product is for research purpose only.)


Glycogen Synthase Kinase (GSK) Inhibitor


PubMed Literature


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