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CAS RN: 22457-89-2 | Product Number: B4711
Benfotiamine
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Purity: >98.0%(T)(HPLC)
Chemical Substance Law (ENCS):
9-1318
Synonyms:
- S-Benzoylthiamine O-Monophosphate
Documents:
| Size | Unit Price | Saitama (Kawaguchi) | Hyogo (Amagasaki) | Stock in other WH |
|---|---|---|---|---|
| 5G |
¥6,600
|
≥40 | 8 | ≥40 |
| 25G |
¥20,000
|
7 | 7 | Contact Us |
Available Stock: Prompt shipment (for products) in Saitama/Hyogo warehouse. Stock in other WH: 2-3 Business Days
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
* Please contact us if you need further information.
* To send your quote request for bulk quantities, please click on the "Request Bulk Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | B4711 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__9H__2__3N__4O__6PS = 466.45 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | 0-10°C |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 22457-89-2 |
| Reaxys Registry Number | 771326 |
| PubChem Substance ID | 253662524 |
| Merck Index (14) | 1041 |
| MDL Number | MFCD00057343 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
Properties (reference)
| Melting Point | 192 °C(dec.) |
GHS
Related Laws:
| Chemical Substance Law (ENCS) |
9-1318 |
| RTECS# | DH6910000 |
Transport Information:
Application
Benfotiamine: S-Acyl Derivative of Thiamine with High Bioavailability
S-benzoylthiamine O-monophoshate (benfotiamine) is a synthetic S-acyl derivative of thiamine (vitamin B1). Benfotiamine is absorbed in vivo much more than water soluble thiamine hydrochloride [T0181]. Benfotiamine increases the levels of intracellular thiamine diphosphate, a cofactor necessary for the activation transketolase, resulting in the reduction of tissue level of advanced glycation end products (AGEs) which can be a factor in the development or worsening of many degenerative diseases, such as diabetes, atherosclerosis, chronic renal failure and Alzheimer's disease.
References
- Pharmacokinetics of thiamine derivatives, especially of benfotiamine (a review)
- D. Loew, Int. J. Clin. Pharmacol. Ther. 1996, 34, 47.
- Efficacy of benfotiamine versus thiamine on function and glycation products of peripheral nerves in diabetic rats
- Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy
- Benfotiamine prevents macro- and microvascular endothelial dysfunction and oxidative stress following a meal rich in advanced glycation end products in individuals with type 2 diabetes
- The multifaceted therapeutic potential of benfotiamine (a review)
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