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CAS RN: 380843-75-4 | Product Number: B4824
Bosutinib
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Purity: >95.0%(T)(HPLC)
Deleterious substance
Synonyms:
- SKI-606
- 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile
- 4-(2,4-Dichloro-5-methoxyanilino)-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile
Product Documents:
| Size | Unit Price | Saitama (Kawaguchi) | Hyogo (Amagasaki) | Stock in other WH |
Shipping Information
|
|---|---|---|---|---|---|
| 250MG |
¥19,500
|
7 | 4 | Contact Us |
* Available Stock: Prompt shipment (for products) in Saitama/Hyogo warehouse. Stock In Other WH: Shipment in about 2-3 Business Days from Saitama warehouse. Please contact us
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* The displayed price is the unit price and does not include consumption tax. The unit prices displayed are the latest and are subject to change without notice.
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
* The displayed price is the unit price and does not include consumption tax. The unit prices displayed are the latest and are subject to change without notice.
* To send your quote request for bulk quantities, please click on the "Request Bulk Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | B4824 |
Purity / Analysis Method 
|
>95.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__6H__2__9Cl__2N__5O__3 = 530.45 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Hygroscopic |
| Packaging and Container
|
250MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 380843-75-4 |
| Reaxys Registry Number | 9100307 |
| MDL Number | MFCD07367846 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Volumetric Analysis) | min. 95.0 % |
| Water | max. 5.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 120 °C |
| Solubility in water | Insoluble |
| Degree of solubility in water | 7 mg/l 25 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H320 : Causes eye irritation. H317 : May cause an allergic skin reaction. H413 : May cause long lasting harmful effects to aquatic life. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P273 : Avoid release to the environment. P272 : Contaminated work clothing should not be allowed out of the workplace. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| Poisonous or Deleterious | Deleterious substance |
| RTECS# | VB0990000 |
Transport Information:
Application
Bosutinib: A Potent ATP-Competitive Tyrosine Kinase Inhibitor
Bosutinib (SKI-606) is a potent ATP-competitive tyrosine kinase inhibitor. Bosutinib has been reported to inhibit the Bcr-Abl kinase, which promotes chronic myeloid leukemia (CML). Inhibition of Bcr-Abl tyrosine kinase activity or signaling proteins activated by Bcr-Abl in CML cells blocks proliferation and causes apoptotic cell death. Bosutinib is also inhibits the phosphorylation of cellular signaling proteins, including Src-family kinases (Src, Lyn, and Hck) and STAT5. (The product is for research purpose only.)
References
- SKI-606, a 4-Anilino-3-quinolinecarbonitrile Dual Inhibitor of Src and Abl Kinases, Is a Potent Antiproliferative Agent against Chronic Myelogenous Leukemia Cells in Culture and Causes Regression of K562 Xenografts in Nude Mice
- In vitro and in vivo Activity of SKI-606, a Novel Src-Abl Inhibitor, against Imatinib-Resistant Bcr-Abl+ Neoplastic Cells
- Global target profile of the kinase inhibitor bosutinib in primary chronic myeloid leukemia cells
- Bosutinib: A Potent Second-Generation Tyrosine Kinase Inhibitor (a review)
Product Documents (Note: Some products will not have analytical charts available.)
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Specifications
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